Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans.

Animals Antitubercular Agents / pharmacokinetics Central Nervous System / metabolism Female Humans Male Mycobacterium tuberculosis / drug effects Nitroimidazoles / pharmacokinetics Oxazoles / pharmacokinetics Rabbits Treatment Outcome Tuberculosis, Meningeal / drug therapy Tuberculosis, Multidrug-Resistant / drug therapy
central nervous system infections delamanid drug resistance meningitis tuberculosis

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
10 2019
Historique:
received: 03 05 2019
accepted: 28 07 2019
pubmed: 7 8 2019
medline: 8 7 2020
entrez: 7 8 2019
Statut: epublish

Résumé

Central nervous system tuberculosis (TB) is devastating and affects vulnerable populations. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculous meningitis (TBM) specifically are nearly uniformly fatal, with little information being available to guide the treatment of these patients. Delamanid (DLM), a nitro-dihydro-imidazooxazole, is a new, well-tolerated anti-TB drug with a low MIC (1 to 12 ng/ml) against

Identifiants

DOI: 10.1128/AAC.00913-19 PMID: 31383662 PMC: PMC6761520
pubmed: 31383662
pii: AAC.00913-19
doi: 10.1128/AAC.00913-19
pmc: PMC6761520
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Nitroimidazoles 0
OPC-67683 0
Oxazoles 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD047349
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145436
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB020539
Pays : United States
Organisme : NIH HHS
ID : S10 OD023524
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

Références

Antimicrob Agents Chemother. 2010 Aug;54(8):3402-7
pubmed: 20498324
Biol Pharm Bull. 2014;37(11):1727-35
pubmed: 25366478
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5600-3
pubmed: 27324761
J Infect Dis. 2005 Jul 1;192(1):79-88
pubmed: 15942897
Pediatrics. 1998 Nov;102(5):E49
pubmed: 9794979
Antimicrob Agents Chemother. 2017 Sep 22;61(10):
pubmed: 28739779
Antimicrob Agents Chemother. 2001 Dec;45(12):3322-7
pubmed: 11709303
Ther Clin Risk Manag. 2015 May 13;11:779-91
pubmed: 25999726
N Engl J Med. 2016 Jan 14;374(2):124-34
pubmed: 26760084
Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):573-81
pubmed: 17696807
Antimicrob Agents Chemother. 2011 Jan;55(1):239-45
pubmed: 20937781
Int J Tuberc Lung Dis. 2011 Jul;15(7):949-54
pubmed: 21682970
Antimicrob Agents Chemother. 2012 Jun;56(6):3027-31
pubmed: 22430968
Antimicrob Agents Chemother. 2017 May 24;61(6):
pubmed: 28373190
PLoS One. 2011;6(5):e20077
pubmed: 21625509
Pediatrics. 2009;123(1):e1-8
pubmed: 19367678
Clin Infect Dis. 2016 Aug 1;63(3):356-62
pubmed: 27169478
Dev Med Child Neurol. 2016 May;58(5):461-8
pubmed: 26888419
J Infect Dis. 2005 Dec 15;192(12):2134-41
pubmed: 16288379
Drugs. 2014 Jun;74(9):1041-5
pubmed: 24923253
Biopharm Drug Dispos. 2017 May;38(4):301-312
pubmed: 28092695
Dis Model Mech. 2016 Dec 1;9(12):1497-1506
pubmed: 27935825
Antimicrob Agents Chemother. 2016 May 23;60(6):3316-22
pubmed: 26976868
Int J Antimicrob Agents. 2015 May;45(5):496-503
pubmed: 25703312
Sci Transl Med. 2018 Dec 5;10(470):
pubmed: 30518610
Antimicrob Agents Chemother. 2018 Nov 26;62(12):
pubmed: 30224533
Nat Immunol. 2018 Jun;19(6):521-525
pubmed: 29777209
Drug Metab Dispos. 2015 Aug;43(8):1267-76
pubmed: 26055620
Trends Pharmacol Sci. 2010 Jun;31(6):246-54
pubmed: 20417575
Clin Infect Dis. 2017 Feb 15;64(4):401-407
pubmed: 27927856
Clin Infect Dis. 2017 Feb 15;64(4):501-509
pubmed: 28172588
Antimicrob Agents Chemother. 2012 Jun;56(6):3074-9
pubmed: 22470117
Lancet Respir Med. 2019 Mar;7(3):249-259
pubmed: 30630778
Int J Antimicrob Agents. 2016 Oct;48(4):415-21
pubmed: 27526979
Clin Pharmacol Ther. 2015 Dec;98(6):622-9
pubmed: 26260983
Neuropharmacology. 2014 Oct;85:548-53
pubmed: 24973705
Dev Med Child Neurol. 2002 Aug;44(8):522-6
pubmed: 12206617
Antimicrob Agents Chemother. 2016 Sep 23;60(10):5976-85
pubmed: 27458223
Antimicrob Agents Chemother. 2014 Oct;58(10):6297-301
pubmed: 25092692
PLoS Med. 2006 Nov;3(11):e466
pubmed: 17132069
Clin Microbiol Rev. 2010 Oct;23(4):858-83
pubmed: 20930076
Infect Drug Resist. 2013 Oct 22;6:163-74
pubmed: 24187505
Antimicrob Agents Chemother. 2012 Feb;56(2):708-14
pubmed: 22123680
Lancet Infect Dis. 2014 Oct;14(10):947-57
pubmed: 25108337
Lancet Infect Dis. 2013 Jan;13(1):27-35
pubmed: 23103177

Auteurs

Elizabeth W Tucker (EW)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
ORCID: 0000-0002-0971-3635

Lisa Pieterse (L)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Matthew D Zimmerman (MD)

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.

Zarir F Udwadia (ZF)

P.D. National Hospital and Medical Research Centre, Mumbai, India.

Charles A Peloquin (CA)

University of Florida College of Pharmacy, Gainesville, Florida, USA.
Emerging Pathogens Institute, Gainesville, Florida, USA.
ORCID: 0000-0001-9002-7052

Maria Tarcela Gler (MT)

Makati Medical Center, Makati City, Philippines.

Shashank Ganatra (S)

P.D. National Hospital and Medical Research Centre, Mumbai, India.

Jeffrey A Tornheim (JA)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Prerna Chawla (P)

P.D. National Hospital and Medical Research Centre, Mumbai, India.

Janice C Caoili (JC)

Emerging Pathogens Institute, Gainesville, Florida, USA.

Brittaney Ritchie (B)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Sanjay K Jain (SK)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Véronique Dartois (V)

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
ORCID: 0000-0001-9470-5009

Kelly E Dooley (KE)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA kdooley1@jhmi.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Delamanid Central Nervous System...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Delamanid Central Nervous System...
questionsmedicales.fr › Système nerveux › Système nerveux central › Delamanid Central Nervous System...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Delamanid Central Nervous System...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Delamanid Central Nervous System...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › Delamanid Central Nervous System...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Delamanid Central Nervous System...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Delamanid Central Nervous System...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Delamanid Central Nervous System...
questionsmedicales.fr › Maladies du système nerveux › Méningite › Méningite bactérienne › Méningite tuberculeuse › Delamanid Central Nervous System...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › Delamanid Central Nervous System...