Clinical associations with telomere length in chronic spinal cord injury.
Adult
Age Factors
Aged
Aged, 80 and over
Chronic Disease
Cohort Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Mobility Limitation
Spinal Cord Injuries
/ diagnosis
Telomere
/ physiology
Telomere Homeostasis
/ physiology
Urinary Bladder Diseases
/ diagnosis
Wheelchairs
/ adverse effects
Journal
Spinal cord
ISSN: 1476-5624
Titre abrégé: Spinal Cord
Pays: England
ID NLM: 9609749
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
07
04
2019
accepted:
19
07
2019
revised:
18
07
2019
pubmed:
7
8
2019
medline:
1
7
2020
entrez:
7
8
2019
Statut:
ppublish
Résumé
Cross-sectional study OBJECTIVES: To determine clinical factors associated with telomere length in persons with chronic spinal cord injury (SCI). Veterans Affairs Medical Center, Boston, MA. Two hundred seventy-eight participants with chronic SCI provided blood samples for measurement of C-reactive protein (CRP), interleukin-6 (IL-6), and telomere length, completed respiratory health questionnaires, underwent dual X-ray absorptiometry (DXA) to assess body fat, and completed spirometry. High-throughput real-time PCR assays were used to assess telomere length in leukocyte genomic DNA. Linear regression models were used to assess cross-sectional associations with telomere length. Telomere length was inversely related to age (p < 0.0001). In age-adjusted models, gender, race, injury duration, %-total and %-trunk fat, body mass index (BMI), %-predicted forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV Our results suggest that clinical characteristics such as decreased mobility and bladder dysfunction that are common in individuals with more severe SCI are associated with shorter telomere length.
Identifiants
pubmed: 31383950
doi: 10.1038/s41393-019-0336-7
pii: 10.1038/s41393-019-0336-7
pmc: PMC6940383
mid: NIHMS1535276
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1084-1093Subventions
Organisme : RRD VA
ID : I01 RX000792
Pays : United States
Organisme : VHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development)
ID : I01RX000596
Organisme : NIAMS NIH HHS
ID : R01 AR059270
Pays : United States
Organisme : VHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development)
ID : B6618R
Organisme : VHA Office of Research and Development | Rehabilitation Research and Development Service (VA Rehabilitation Research and Development)
ID : I01RX000792
Organisme : RRD VA
ID : I21 RX000596
Pays : United States
Commentaires et corrections
Type : ErratumIn
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