Update on novel pharmacological therapies for osteoarthritis.
DMOAD
cartilage
corticosteroids
inflammation
nociceptive pain
osteoarthritis
synovitis
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
12
2018
accepted:
25
06
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
8
2019
Statut:
epublish
Résumé
Osteoarthritis (OA) is a chronic painful arthritis with increasing global prevalence. Current management involves non-pharmacological interventions and commonly used pharmacological treatments that generally have limited analgesic efficacy and multiple side effects. New treatments are therefore required to relieve patient symptoms and disease impact. A number of existing pharmacological therapies have been recently trialled in OA. These include extended-release triamcinolone and conventional disease-modifying anti-rheumatic drugs (DMARDs) used in the management of rheumatoid arthritis; generally, DMARDs have not shown a benefit in treating OA. Novel analgesic therapies are in development, including those targeting peripheral pain pathways. Disease-modifying osteoarthritis drugs (DMOADs) target key tissues in the OA pathophysiology process and aim to prevent structural progression; a number of putative DMOADs are in phase II development. There is preliminary evidence of structural improvement with some of these therapies but without concomitant symptom improvement, raising new considerations for future DMOAD trials.
Identifiants
pubmed: 31384314
doi: 10.1177/1759720X19864492
pii: 10.1177_1759720X19864492
pmc: PMC6651659
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X19864492Déclaration de conflit d'intérêts
Conflict of interest statement: AG reports no conflicts. PGC reports speakers’ bureaus or consultancies for Abbvie, Astra Zeneca, BMS, Centrexion, Flexion Therapeutics, GlaxoSmithKline, Merck Serono, Novartis, Pfizer and Samumed.
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