The profiles of dysbiotic microbial communities.
bioreactors
culturomics
gut microbiome
metabolomics
metagenomics
organoids
Journal
AIMS microbiology
ISSN: 2471-1888
Titre abrégé: AIMS Microbiol
Pays: United States
ID NLM: 101697141
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
11
2018
accepted:
17
03
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
8
2019
Statut:
epublish
Résumé
Alterations in the human gut microbiota play an important role in disease pathogenesis. Although next-generation sequencing has provided observational evidence linking shifts in gut microbiota composition to alterations in the human host, underlying mechanisms remain elusive. Metabolites generated within complex microbial communities and at the crossroads with host cells may be able to explain the impact of the gut microbiome on human homeostasis. Emerging technologies including novel culturing protocols, microfluidic systems, engineered organoids, and single-cell imaging approaches are providing new perspectives from which the gut microbiome can be studied paving the way to new diagnostic markers and personalized therapeutic interventions.
Identifiants
pubmed: 31384705
doi: 10.3934/microbiol.2019.1.87
pii: microbiol-05-01-087
pmc: PMC6646933
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
87-101Déclaration de conflit d'intérêts
Conflict of interest: All authors declare no conflicts of interest in this paper.
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