Risk factors for coronary artery disease in young patients with stable angina pectoris
Coronary artery disease
stable angina pectoris
young patients
Journal
Turkish journal of medical sciences
ISSN: 1303-6165
Titre abrégé: Turk J Med Sci
Pays: Turkey
ID NLM: 9441758
Informations de publication
Date de publication:
08 08 2019
08 08 2019
Historique:
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
19
2
2020
Statut:
epublish
Résumé
We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP). A total of571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD. Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients. Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.
Sections du résumé
Background/aim
We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP).
Materials and methods
A total of571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD.
Results
Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients.
Conclusion
Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.
Identifiants
pubmed: 31385674
doi: 10.3906/sag-1905-56
pmc: PMC7018258
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
993-998Informations de copyright
This work is licensed under a Creative Commons Attribution 4.0 International License.
Références
PLoS One. 2015 Sep 18;10(9):e0138067
pubmed: 26381512
Circ Res. 2014 Jun 6;114(12):1959-75
pubmed: 24902978
PLoS One. 2013 Oct 16;8(10):e78475
pubmed: 24147135
Egypt Heart J. 2018 Dec;70(4):233-235
pubmed: 30591735
PLoS One. 2015 Jul 24;10(7):e0133934
pubmed: 26207383
Int J Cardiol. 2011 May 5;148(3):300-4
pubmed: 19942306
Am J Med Sci. 2015 Dec;350(6):479-83
pubmed: 26445306
Eur Heart J. 2002 May;23(9):706-13
pubmed: 11977996
Anatol J Cardiol. 2015 Aug;15(8):640-7
pubmed: 25550173
Am J Med. 2015 Sep;128(9):1015-22.e2
pubmed: 25863153
Heart Lung Circ. 2017 Jun;26(6):566-571
pubmed: 28089789
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Lancet. 2015 Jan 31;385(9966):441-51
pubmed: 24969506
J Am Coll Cardiol. 2002 Nov 20;40(10):1761-8
pubmed: 12446059
ARYA Atheroscler. 2017 Mar;13(2):79-87
pubmed: 29026414
Dis Markers. 2017;2017:4719403
pubmed: 29109596
Am J Med. 2017 Jun;130(6):720-730
pubmed: 28109968
Cardiol J. 2019;26(5):511-518
pubmed: 30234895
Dis Markers. 2018 Sep 2;2018:2429160
pubmed: 30245751
Isr Med Assoc J. 2018 Oct;20(10):613-618
pubmed: 30324777
Circulation. 2016 Jan 12;133(2):139-46
pubmed: 27028434
J Cardiovasc Transl Res. 2018 Dec;11(6):517-523
pubmed: 30276618
Cardiovasc Interv Ther. 2018 Apr;33(2):154-162
pubmed: 28585049
Circulation. 2008 Mar 4;117(9):1216-27
pubmed: 18316498
BMC Cardiovasc Disord. 2018 Aug 31;18(1):178
pubmed: 30170547
Am J Kidney Dis. 2009 Jun;53(6):982-92
pubmed: 19339088
Atherosclerosis. 2017 Oct;265:102-109
pubmed: 28881267
Am J Kidney Dis. 2013 Oct;62(4):691-702
pubmed: 23769137