Global celebrities' effect on health awareness among Jordanians: A study using the case of Angelina Jolie.
Adult
Awareness
Breast Neoplasms
/ genetics
Cross-Sectional Studies
Decision Making
Famous Persons
Female
Genetic Predisposition to Disease
Genetic Testing
/ statistics & numerical data
Humans
Jordan
Male
Middle Aged
Ovarian Neoplasms
/ genetics
Prophylactic Mastectomy
Prophylactic Surgical Procedures
Surveys and Questionnaires
Angelina Jolie Effect
Jordan
awareness
breast cancer
community
ethics
family history
genetic counseling
genetic testing
ovarian cancer
Journal
Journal of genetic counseling
ISSN: 1573-3599
Titre abrégé: J Genet Couns
Pays: United States
ID NLM: 9206865
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
01
2019
revised:
29
06
2019
accepted:
03
07
2019
pubmed:
7
8
2019
medline:
7
7
2020
entrez:
7
8
2019
Statut:
ppublish
Résumé
Celebrities' health decisions have long been associated with heightened awareness and health trend changes. This is the first study conducted in an Arab population investigating the impact of international celebrity news on local communities using the case of Angelia Jolie's (AJ) prophylactic mastectomy and oophorectomy surgeries. The objective was to measure the effect of publicized medical information on cancer genetic testing knowledge, attitudes, and practices (KAP). This is a cross-sectional study using a semi-structured, self-administered questionnaire for clinic visitors at the King Hussein Cancer Center (KHCC). We had predominantly female (n = 262, 66.3%) and healthy participants (n = 248, 66.5%). Approximately 80.7% (n = 330) recognized AJ, the actress, and of these, 71% (n = 232) were aware of her recent diagnosis and prophylactic surgeries. Males reported a higher knowledge score (p < .001). However, females had more initiative to seek information (18.3% vs. 10.1%; p = .04). People aware of Angelina's prophylactic procedures were inclined to seek information regarding cancer genetics (20.8% vs. 9.6% p = .003). Breast and ovarian cancer patients were more likely than other cancer patients to encourage family members to undergo prophylactic surgery in case of BRCA1/2 mutations (39.2% vs. 17.1% p = .03). Ninety-three percent of the sample lacked knowledge regarding the availability of cancer genetic testing in Jordan. Results highlight a clear effect of celebrity medical news on our population, as well as openness to consider genetic testing as an early detection tool for women with a family history of breast and/or ovarian cancer. Generalization of these results to the population of Jordan requires further studies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1021-1028Informations de copyright
© 2019 National Society of Genetic Counselors.
Références
Abdel-Razeq, H., Al-Omari, A., Zahran, F., & Arun, B. (2018). Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan. BMC Cancer, 18(1), 152. https://doi.org/10.1186/s12885-018-4079-1
Ahram, M., Soubani, M., Abu Salem, L., Saker, H., & Ahmad, M. (2015). Knowledge, attitudes, and practice regarding genetic testing and genetic counselors in Jordan: A population-based survey. Journal Genetic Counsling, 24(6), 1001-1010. https://doi.org/10.1007/s10897-015-9839-3
Al Bakir, M., & Gabra, H. (2014). The molecular genetics of hereditary and sporadic ovarian cancer: Implications for the future. British Medical Bulletin, 112(1), 57-69. https://doi.org/10.1093/bmb/ldu034
Al-Kuraya, K., Schraml, P., Sheikh, S., Amr, S., Torhorst, J., Tapia, C., … Sauter, G. (2005). Predominance of high-grade pathway in breast cancer development of Middle East women. Modern Pathology, 18(7), 891-897. https://doi.org/10.1038/modpathol.3800408
Amayiri, N., Tabori, U., Campbell, B., Bakry, D., Aronson, M., Durno, C. … Al-Hussaini, M. (2016). High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan. International Journal of Cancer, 138(2), 380-385. https://doi.org/10.1002/ijc.29724
Amemiya, Y., Bacopulos, S., Al-Shawarby, M., Al-Tamimi, D., Naser, W., Ahmed, A., … Seth, A. (2015). A comparative analysis of breast and ovarian cancer-related gene mutations in Canadian and Saudi Arabian patients with breast cancer. Anticancer Research, 35(5), 2601-2610. http://www.ncbi.nlm.nih.gov/pubmed/25964535
Amin, T. T., Al-Wadaani, H. A., Al-Quaimi, M. M., Aldairi, N. A., Alkhateeb, J. M., & Al-Jaafari, A. A. (2012). Saudi women's interest in breast cancer gene testing: Possible influence of awareness, perceived risk and socio-demographic factors. Asian Pacific Journal of Cancer Prevention, 13(8), 3879-3887. https://doi.org/10.7314/APJCP.2012.13.8.3879
Atoum, M. F., & Al-Kayed, S. A. (2004). Mutation analysis of the breast cancer gene BRCA1 among breast cancer Jordanian females. Saudi Medical Journal, 25(1), 60-63. http://www.ncbi.nlm.nih.gov/pubmed/14758382
Borzekowski, D. L., Guan, Y., Smith, K. C., Erby, L. H., & Roter, D. L. (2014). The Angelina effect: Immediate reach, grasp, and impact of going public. Genetics in Medicine, 16(7), 516-521. https://doi.org/10.1038/gim.2013.181
Bottorff, J. L., Ratner, P. A., Balneaves, L. G., Richardson, C. G., McCullum, M., Hack, T., … Buxton, J. (2002). Women's interest in genetic testing for breast cancer risk: The influence of sociodemographics and knowledge. Cancer Epidemiology Biomarkers and Prevention, 11(1), 89-95. https://www.ncbi.nlm.nih.gov/pubmed/11815405
Chapman, S., McLeod, K., Wakefield, M., & Holding, S. (2005). Impact of news of celebrity illness on breast cancer screening: Kylie Minogue's breast cancer diagnosis. The Medical Journal of Australia, 183(5), 247-250. http://www.ncbi.nlm.nih.gov/pubmed/16138798
Chen, S., & Parmigiani, G. (2007). Meta-analysis of BRCA1 and BRCA2 penetrance. Journal of Clinical Oncology, 25(11), 1329-1333. https://doi.org/10.1200/JCO.2006.09.1066
Daly, M. B., Montgomery, S., Bingler, R., & Ruth, K. (2016). Communicating genetic test results within the family: Is it lost in translation? A survey of relatives in the randomized six-step study. Familial Cancer, 15(4), 697-706. https://doi.org/10.1007/s10689-016-9889-1
Edlich, R. F., Winters, K. L., & Lin, K. Y. (2005). Breast cancer and ovarian cancer genetics. Journal of Long-Term Effects of Medical Implants, 15(5), 533-545. https://doi.org/10.1615/JLongTermEffMedImplants.v15.i5.60
El-Shanti, H. (2001). The impact of genetic diseases on Jordanians: Strategies towards prevention. Journal of Biomedicine and Biotechnology, 1(1), 45-47. https://doi.org/10.1155/S1110724301000092
Evans, D. G. R., Barwell, J., Eccles, D. M., Collins, A., Izatt, L., Jacobs, C., … Murray, A. (2014). The Angelina Jolie effect: How high celebrity profile can have a major impact on provision of cancer related services. Breast Cancer Research, 16(5), 442. https://doi.org/10.1186/s13058-014-0442-6
Evans, D. G., Wisely, J., Clancy, T., Lalloo, F., Wilson, M., Johnson, R., … Howell, A. (2015). Longer term effects of the Angelina Jolie effect: Increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women. Breast Cancer Research, 17, 143. https://doi.org/10.1186/s13058-015-0650-8
Evers, C., Fischer, C., Dikow, N., & Schott, S. (2017). Familial breast cancer: Genetic counseling over time, including patients expectations and initiators considering the Angelina Jolie effect. PLoS ONE, 12(5), e0177893. https://doi.org/10.1371/journal.pone.0177893
Finch, A. P., Lubinski, J., Moller, P., Singer, C. F., Karlan, B., Senter, L., … Narod, S. A. (2014). Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. Journal of Clinical Oncology, 32(15), 1547-1553. https://doi.org/10.1200/JCO.2013.53.2820
Freedman, R., Mountain, H., Karina, D., & Schofield, L. (2017). A retrospective exploration of the impact of the 'Angelina Jolie Effect' on the single state-wide familial cancer program in Perth, Western Australia. Journal of Genetic Counseling, 26(1), 52-62. https://doi.org/10.1007/s10897-016-9982-5
Hagag, E., Shwaireb, M., Coffa, J., & El Wakil, A. (2013). Screening for BRCA1 large genomic rearrangements in female Egyptian hereditary breast cancer patients. Eastern Mediterranean Health Journal, 19(3), 255-262. https://doi.org/10.26719/2013.19.3.255
Hall, J., Gray, S., A’Hern, R., Shanley, S., Watson, M., Kash, K., … Eeles, R. (2009). Genetic testing for BRCA1: Effects of a randomised study of knowledge provision on interest in testing and long term test uptake; implications for the NICE guidelines. Familial Cancer, 8(1), 5-13. https://doi.org/10.1007/s10689-008-9201-0
Hamamy, H., Al-Hait, S., Alwan, A., & Ajlouni, K. (2007). Jordan: Communities and community genetics. Community Genetics, 10(1), 52-60. https://doi.org/10.1159/000096282
Hoffman, S. J., & Tan, C. (2015). Biological, psychological and social processes that explain celebrities' influence on patients' health-related behaviors. Archives of Public Health, 73(1), 3. https://doi.org/10.1186/2049-3258-73-3
IndexMundi. (2018). Jordan Age structure. https://www.indexmundi.com/jordan/age_structure.html. Accessed 27 April 2019.
Jordan Cancer Registry Report. (2014). Cancer Incidence in Jordan.
Juthe, R. H., Zaharchuk, A., & Wang, C. (2015). Celebrity disclosures and information seeking: The case of Angelina Jolie. Genetics in Medicine, 17(7), 545-553. https://doi.org/10.1038/gim.2014.141
Kamenova, K., Reshef, A., & Caulfield, T. (2014). Angelina Jolie's faulty gene: Newspaper coverage of a celebrity's preventive bilateral mastectomy in Canada, the United States, and the United Kingdom. Genetics in Medicine, 16(7), 522-528. https://doi.org/10.1038/gim.2013.199
Kelaher, M., Cawson, J., Miller, J., Kavanagh, A., Dunt, D., & Studdert, D. M. (2008). Use of breast cancer screening and treatment services by Australian women aged 25-44 years following Kylie Minogue's breast cancer diagnosis. International Journal of Epidemiology, 37(6), 1326-1332. https://doi.org/10.1093/ije/dyn090
Kennedy, S. J., & Al-Saffar, M. (2010). Genetic counseling in the middle east. In A. S. Teebi (Ed.), Genetic disorders among Arab populations, (2nd edn., pp. 725-740). Berlin: Springer.
Khaberni. (2015). AJ Removes ovaries for fear of cancer. Retrieved from http://www.khaberni.com/news/144912. Accessed 27 March 2015.
Kobayashi, H., Ohno, S., Sasaki, Y., & Matsuura, M. (2013). Hereditary breast and ovarian cancer susceptibility genes (review). Oncology Reports, 30(3), 1019-1029. https://doi.org/10.3892/or.2013.2541
Laraqui, A., Uhrhammer, N., ElRhaffouli, H., Sekhsokh, Y., Lahlou-Amine, I., Bajjou, T. … Amzazi, S. (2015). BRCA genetic screening in Middle Eastern and North African: Mutational spectrum and founder BRCA1 mutation (c.798_799delTT) in North African. Disease Markers, 2015, 194293. https://doi.org/10.1155/2015/194293
Lee, S., Gedleh, A., Hill, J. A., Qaiser, S., Umukunda, Y., Odiyo, P., … Dimaras, H. (2018). In their own words: a qualitative study of Kenyan breast cancer survivors' knowledge, experiences, and attitudes regarding breast cancer genetics. Journal of Global Oncology, 4, 1-9. https://doi.org/10.1200/jgo.17.00061
Liede, A., Cai, M., Crouter, T. F., Niepel, D., Callaghan, F., & Evans, D. G. (2018). Risk-reducing mastectomy rates in the US: A closer examination of the Angelina Jolie effect. Breast Cancer Research and Treatment, 171(2), 435-442. https://doi.org/10.1007/s10549-018-4824-9
Lipkus, I. M., Iden, D., Terrenoire, J., & Feaganes, J. R. (1999). Relationships among breast cancer concern, risk perceptions, and interest in genetic testing for breast cancer susceptibility among African-American women with and without a family history of breast cancer. Cancer Epidemiology Biomarkers and Prevention, 8(6), 533-539.
MacNew, H. G., Rudolph, R., Brower, S. T., Beck, A. N., & Meister, E. A. (2010). Assessing the knowledge and attitudes regarding genetic testing for breast cancer risk in our region of southeastern Georgia. Breast Journal, 16(2), 189-192. https://doi.org/10.1111/j.1524-4741.2009.00880.x
Mellon, S., Gauthier, J., Cichon, M., Hammad, A., & Simon, M. S. (2013). Knowledge, attitudes, and beliefs of Arab-American women regarding inherited cancer risk. Journal of Genetic Counseling, 22(2), 268-276. https://doi.org/10.1007/s10897-012-9546-2
Milne, R. L., Osorio, A., Cajal, T. R. Y., Vega, A., Llort, G., de la Hoya, M., … Benitez, J. (2008). The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain. Clinical Cancer Research, 14(9), 2861-2869. https://doi.org/10.1158/1078-0432.ccr-07-4436
Nattinger, A. B., Hoffmann, R. G., Howell-Pelz, A., & Goodwin, J. S. (1998). Effect of Nancy Reagan's mastectomy on choice of surgery for breast cancer by US women. JAMA, 279(10), 762-766. https://doi.org/10.1001/jama.279.10.762
Obeidat, R. (2015). Decision-making preferences of Jordanian women diagnosed with breast cancer. Supportive Care in Cancer, 23(8), 2281-2285. https://doi.org/10.1007/s00520-014-2594-4
Reane, P. (2013). Angelina Jolie has double mastectomy to elude cancer. Retrieved from https://www.reuters.com/...angelinajolie-mastectomy/angelina-jolie-has-double-mastec
Reuters. (2015). Angelina Jolie has ovaries removed over cancer concern. Retrieved from https://www.reuters.com/article/people-angelinajolie-cancer-idUSL2N0WQ08220150324
Salhab, M., Bismohun, S., & Mokbel, K. (2010). Risk-reducing strategies for women carrying BRCA1/2 mutations with a focus on prophylactic surgery. BMC Womens Health, 10, 28. https://doi.org/10.1186/1472-6874-10-28
Sheppard, V. B., Graves, K. D., Christopher, J., Hurtado-de-Mendoza, A., Talley, C., & Williams, K. P. (2014). African American women's limited knowledge and experiences with genetic counseling for hereditary breast cancer. Journal of Geneic Counseling, 23(3), 311-322. https://doi.org/10.1007/s10897-013-9663-6
Staudigl, C., Pfeiler, G., Hrauda, K., Renz, R., Berger, A., Lichtenschopf, R., … Tea, M.-K. (2016). Changes of socio-demographic data of clients seeking genetic counseling for hereditary breast and ovarian cancer due to the "Angelina Jolie Effect". BMC Cancer, 16, 436. https://doi.org/10.1186/s12885-016-2472-1
Yousef, Y. A., Tbakhi, A., Al-Hussaini, M., AlNawaiseh, I., Saab, A., Afifi, A., … Mehyar, M. (2018). Mutational analysis of the RB1 gene and the inheritance patterns of retinoblastoma in Jordan. Familial Cancer, 17(2), 261-268. https://doi.org/10.1007/s10689-017-0027-5