The golden hour of polymyxin B hemoperfusion in endotoxic shock: The basis for sequential extracorporeal therapy in sepsis.
endotoxic shock
hemoperfusion
sequential extracorporeal therapy
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
12
06
2019
revised:
23
07
2019
accepted:
29
07
2019
pubmed:
7
8
2019
medline:
18
11
2020
entrez:
7
8
2019
Statut:
ppublish
Résumé
Endotoxin is recognized as a major trigger of the immune response leading to pro- and anti-inflammatory cytokine release, activation of the coagulation cascade, vasoplegic shock, and multiple organ dysfunction syndrome. A beneficial effect could be achieved through extracorporeal adsorption of circulating endotoxins in the blood as adjunctive treatment for unresponsive endotoxic shock. However, the precise clinical indication for its initiation is widely debated in the literature. Similar to the source control, microbiological cultures and antibiotics administration, endotoxin activity assay evaluation at regular intervals, and the targeted use of PMX-B hemoperfusion could be lifesaving and adequate within the golden hour for the diagnosis and treatment of endotoxic shock.
Identifiants
pubmed: 31386769
doi: 10.1111/aor.13550
pmc: PMC7003912
doi:
Substances chimiques
Endotoxins
0
Polymyxin B
J2VZ07J96K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
184-186Informations de copyright
© 2019 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals, Inc.
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