Cytotoxic ergosterols from cultures of the basidiomycete Psathyrella candolleana.

Antineoplastic Agents / isolation & purification Basidiomycota / chemistry Cell Line, Tumor China Drug Screening Assays, Antitumor Ergosterol / isolation & purification Humans Molecular Structure
Cytotoxicity Ergosterol Psathergosterols A–C Psathyrella candolleana

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 12 07 2019
revised: 01 08 2019
accepted: 02 08 2019
pubmed: 7 8 2019
medline: 4 12 2019
entrez: 7 8 2019
Statut: ppublish

Résumé

Three newly isolated ergosterols, psathergosterols A-C (1-3), together with two known ones (4 and 5), have been isolated from cultures of the basdiomycete Psathyrella candolleana. Their structures with the absolute configuration were elucidated by means of spectroscopic methods and the single crystal X-ray diffraction. Compounds 2-4 exhibited certain cytotoxicities to five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).

Identifiants

DOI: 10.1016/j.fitote.2019.104289 PMID: 31386896
pubmed: 31386896
pii: S0367-326X(19)31450-9
doi: 10.1016/j.fitote.2019.104289
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Ergosterol Z30RAY509F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104289

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Ya-Pei Liu (YP)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China.

Chao-Jun Pu (CJ)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China.

Meng Wang (M)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China.

Juan He (J)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China.

Zheng-Hui Li (ZH)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China.

Tao Feng (T)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China. Electronic address: tfeng@mail.scuec.edu.cn.

Jie Xie (J)

State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing 400715, China. Electronic address: healthjie@163.com.

Ji-Kai Liu (JK)

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China. Electronic address: liujikai@mail.scuec.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Cholestènes › Ergostérol › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytotoxic ergosterols from cultures of the...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Cytotoxic ergosterols from cultures of the...