Asthma from immune pathogenesis to precision medicine.

Animals Anti-Asthmatic Agents / therapeutic use Asthma / immunology Biological Products / therapeutic use Humans Immunity, Innate Phenotype Precision Medicine
Adaptive immunity Asthma Endotypes Innate immunity Phenotypes Precision medicine

Journal

Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458

Informations de publication

Date de publication:
12 2019
Historique:
received: 01 05 2019
revised: 28 07 2019
accepted: 31 07 2019
pubmed: 8 8 2019
medline: 2 6 2020
entrez: 8 8 2019
Statut: ppublish

Résumé

Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.

Identifiants

DOI: 10.1016/j.smim.2019.101294 PMID: 31387788
pubmed: 31387788
pii: S1044-5323(19)30001-6
doi: 10.1016/j.smim.2019.101294
pii:
doi:

Substances chimiques

Anti-Asthmatic Agents 0
Biological Products 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101294

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Kareem Khalaf (K)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Giovanni Paoletti (G)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy.

Francesca Puggioni (F)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy.

Francesca Racca (F)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Fabrizio De Luca (F)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Veronica Giorgis (V)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Giorgio Walter Canonica (GW)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy.

Enrico Heffler (E)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy. Electronic address: enrico.heffler@hunimed.eu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Asthma from immune pathogenesis to precision medicine.
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Asthma from immune pathogenesis to precision medicine.