Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
10
04
2019
accepted:
09
05
2019
entrez:
8
8
2019
pubmed:
8
8
2019
medline:
8
8
2019
Statut:
epublish
Résumé
Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism and energy balance in the human body. Conversely, LPL expression is almost absent in normal adult livers. Therefore, its physiological role in the liver remains unknown. We aimed to elucidate the role of LPL in the pathophysiology of nonalcoholic steatohepatitis (NASH), a hepatic manifestation of obesity. Hepatic stellate cell (HSC)-specific LPL-knockout (
Identifiants
pubmed: 31388630
doi: 10.1002/hep4.1383
pii: HEP41383
pmc: PMC6671781
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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