Evaluation of the efficacy of lipotransfer to manage radiation-induced fibrosis and volume defects in head and neck oncology.
Adipose Tissue
/ transplantation
Adult
Aged
Carcinoma, Squamous Cell
/ mortality
Cohort Studies
Esthetics
Female
Fibrosis
/ etiology
Head and Neck Neoplasms
/ mortality
Humans
Male
Middle Aged
Neoplasm Invasiveness
/ pathology
Neoplasm Staging
Quality of Life
Radiotherapy, High-Energy
/ adverse effects
Plastic Surgery Procedures
/ methods
Retrospective Studies
Skin
/ pathology
fat grafting
head and neck oncology
lipotransfer
radiation-induced fibrosis
volume defects
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
04
03
2019
revised:
03
07
2019
accepted:
11
07
2019
pubmed:
8
8
2019
medline:
12
9
2020
entrez:
8
8
2019
Statut:
ppublish
Résumé
Multimodality treatment for head and neck cancer leads to substantial functional and esthetic impairment mainly manifested as radiation-induced skin fibrosis (RIF) in combination with volumetric defects and reduction in neck mobility. This study assessed the impact of lipotransfer as part of secondary surgical procedure(s) in patients treated for head and neck malignancies. Retrospective analysis was performed between 2005 and 2016. All patients with a history of head and neck malignancy, multimodal treatment including at least surgery or radiotherapy, and at least 2-year disease-free survival were included. Thirty-eight patients (22 men, 16 women) matched the inclusion criteria. Thirty seven (97%) reported esthetic and functional improvements in their RIF and volumetric defect at follow-up of 32 months. Major improvement in esthetic and functional outcome was reported by 24 (63%) patients and surgeons and minor by 13 patients and surgeons (34%) without causing any complications. Lipotransfer was also found to significantly improve patient's psychological health postoperatively as showed by significant improvements in Derriford Appearance Scale (DAS24), Short Form Health Survey (SF-36), and University of Washington Quality of Life Questionnaire (UW-QOL V4) scores (P < .001). Lipotransfer is effective for volume restoration and treating scar and RIF from head and neck defects.
Sections du résumé
BACKGROUND
Multimodality treatment for head and neck cancer leads to substantial functional and esthetic impairment mainly manifested as radiation-induced skin fibrosis (RIF) in combination with volumetric defects and reduction in neck mobility. This study assessed the impact of lipotransfer as part of secondary surgical procedure(s) in patients treated for head and neck malignancies.
METHODS
Retrospective analysis was performed between 2005 and 2016. All patients with a history of head and neck malignancy, multimodal treatment including at least surgery or radiotherapy, and at least 2-year disease-free survival were included. Thirty-eight patients (22 men, 16 women) matched the inclusion criteria.
RESULTS
Thirty seven (97%) reported esthetic and functional improvements in their RIF and volumetric defect at follow-up of 32 months. Major improvement in esthetic and functional outcome was reported by 24 (63%) patients and surgeons and minor by 13 patients and surgeons (34%) without causing any complications. Lipotransfer was also found to significantly improve patient's psychological health postoperatively as showed by significant improvements in Derriford Appearance Scale (DAS24), Short Form Health Survey (SF-36), and University of Washington Quality of Life Questionnaire (UW-QOL V4) scores (P < .001).
CONCLUSIONS
Lipotransfer is effective for volume restoration and treating scar and RIF from head and neck defects.
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3647-3655Subventions
Organisme : European Association for Cranio Maxillo Facial Surgery
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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