Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice.
Administration, Oral
Akkermansia
/ immunology
Animals
Apolipoprotein E3
/ genetics
Disease Models, Animal
Hypercholesterolemia
/ immunology
Hyperlipidemias
/ immunology
Immunologic Factors
/ pharmacology
Lipid Metabolism
Lipids
/ blood
Lipopolysaccharides
/ blood
Lymph Nodes
/ immunology
Male
Mice, Mutant Strains
Neointima
/ etiology
Probiotics
/ administration & dosage
Akkermansia muciniphila
atherosclerosis
immunity
lipid metabolism
mesenteric lymph nodes
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
09
07
2019
pubmed:
8
8
2019
medline:
17
7
2021
entrez:
8
8
2019
Statut:
ppublish
Résumé
Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti-inflammatory properties both in the intestine and other organs. The aim is to investigate the effects of oral administration of A. muciniphila on lipid metabolism, immunity, and cuff-induced neointima formation in hyperlipidemic APOE*3-Leiden (E3L).CETP mice. Hyperlipidemic male E3L.CETP mice are daily treated with 2 × 10 Four weeks of treatment with A. muciniphila exerts lipid-lowering and immunomodulatory effects, which are insufficient to inhibit neointima formation in hyperlipidemic E3L.CETP mice.
Identifiants
pubmed: 31389129
doi: 10.1002/mnfr.201900732
pmc: PMC7507188
doi:
Substances chimiques
Apolipoprotein E3
0
Immunologic Factors
0
Lipids
0
Lipopolysaccharides
0
apolipoprotein E3 (Leidein)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900732Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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