Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.
Mesoamerican nephropathy
chronic kidney disease of unknown etiology
core temperature
heat shock
heat stress
hyperthermia
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
pubmed:
8
8
2019
medline:
9
4
2020
entrez:
8
8
2019
Statut:
ppublish
Résumé
An epidemic of chronic kidney disease of unknown etiology (Mesoamerican nephropathy) has emerged in hot regions of Central America. We have demonstrated that dehydration associated with recurrent heat exposure causes chronic kidney disease in animal models. However, the independent influence of core body temperature on kidney injury has not been explored. In the present study, we tested the hypothesis that kidney injury could be accelerated by increasing body temperature independent of external temperature. Wild-type mice were exposed to heat (39.5°C, 30 min, 2 times daily) with or without the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) for 10 days. Core temperature, renal function, proteinuria, and renal histological and biochemical analyses were performed. Isolated mitochondria markers of oxidative stress were evaluated from kidney tissue. DNP increased body core temperature in response to heat by 1°C (42 vs. 41°C), which was transient. The mild increase in temperature correlated with worsening albuminuria (
Identifiants
pubmed: 31390229
doi: 10.1152/ajprenal.00259.2019
pmc: PMC6879947
doi:
Substances chimiques
HSP70 Heat-Shock Proteins
0
2,4-Dinitrophenol
Q13SKS21MN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F1111-F1121Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133545
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117062
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK096030
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132318
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108859
Pays : United States
Références
Science. 2004 Jan 9;303(5655):223-6
pubmed: 14716012
Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F726-F733
pubmed: 29667911
N Engl J Med. 2002 Jun 20;346(25):1978-88
pubmed: 12075060
N Engl J Med. 2019 May 9;380(19):1843-1852
pubmed: 31067373
J Appl Physiol (1985). 2004 Jan;96(1):124-30
pubmed: 12949014
Kidney Int. 2014 Aug;86(2):294-302
pubmed: 24336030
Nephrol Dial Transplant. 2017 Apr 1;32(4):598-602
pubmed: 28407135
J Appl Physiol. 1976 May;40(5):683-7
pubmed: 931894
Eur J Public Health. 2006 Dec;16(6):592-9
pubmed: 16644927
Am J Hum Biol. 2002 Sep-Oct;14(5):609-20
pubmed: 12203815
Am J Physiol. 1978 Nov;235(5):R228-36
pubmed: 727284
Kidney Int. 2018 Mar;93(3):681-690
pubmed: 29162294
Clin Kidney J. 2014 Dec;7(6):519-23
pubmed: 25859368
Clin Nephrol. 2016 Supplement 1;86 (2016)(13):106-109
pubmed: 27469156
Crit Care Nurse. 2015 Feb;35(1):52-9
pubmed: 25639577
Eur J Clin Nutr. 2011 Jun;65(6):663-7
pubmed: 21468093
Trans Am Clin Climatol Assoc. 2009;120:287-95
pubmed: 19768183
Am J Kidney Dis. 2013 Nov;62(5):908-18
pubmed: 23850447
Occup Environ Med. 2017 Jun;74(6):402-409
pubmed: 28093502
Kidney Int. 2015 Apr;87(4):792-9
pubmed: 25229334
Aging Cell. 2008 Aug;7(4):552-60
pubmed: 18505478
J Am Soc Nephrol. 2014 Nov;25(11):2526-38
pubmed: 24876114
Q J Med. 1967 Jul;36(143):277-300
pubmed: 6049763
Med Sci Sports Exerc. 2017 Aug;49(8):1745-1753
pubmed: 28272268
Shock. 2011 May;35(5):466-70
pubmed: 21330950
Environ Res. 2015 Oct;142:746-55
pubmed: 26209462
Scand J Work Environ Health. 2018 Jan 1;44(1):16-24
pubmed: 28691728
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90
pubmed: 19706525
Medicine (Baltimore). 1982 May;61(3):189-97
pubmed: 7078400
Ann N Y Acad Sci. 1994 Apr 15;718:72-81; discussion 81-2
pubmed: 8185253
Kidney Int. 2018 Dec;94(6):1205-1216
pubmed: 30466566
Int J Biol Sci. 2017 Jul 18;13(8):961-975
pubmed: 28924378
Am J Trop Med Hyg. 2017 Oct;97(4):1247-1256
pubmed: 28722618
Kidney Int. 2007 Feb;71(3):266-71
pubmed: 17149371
Eur J Nutr. 2016 Aug;55(5):1831-8
pubmed: 26206564
Front Physiol. 2015 Feb 10;6:36
pubmed: 25713540
Pancreas. 2012 May;41(4):530-4
pubmed: 22158074
Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R57-65
pubmed: 27053647
Environ Res. 2016 May;147:125-32
pubmed: 26866450
Med Sci Sports Exerc. 2005 Aug;37(8):1338-44
pubmed: 16118581
Q J Med. 1970 Apr;39(154):189-99
pubmed: 5449588
J Occup Environ Med. 2019 Mar;61(3):239-250
pubmed: 30575695
Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1472-83
pubmed: 27151892
Nephron Exp Nephrol. 2012;121(3-4):e71-8
pubmed: 23235493