Does glucagon-like peptide-1 induce diuresis and natriuresis by modulating afferent renal nerve activity?
Afferent Pathways
/ drug effects
Animals
Calcitonin Gene-Related Peptide
/ physiology
Denervation
Diuresis
/ drug effects
Glucagon-Like Peptide 1
/ biosynthesis
Glucagon-Like Peptide-1 Receptor
/ biosynthesis
HEK293 Cells
Humans
Kidney
/ drug effects
Kidney Pelvis
/ drug effects
Male
Natriuresis
/ drug effects
Rats
Rats, Sprague-Dawley
Renal Circulation
/ drug effects
Sodium
/ urine
Sympathetic Nervous System
/ drug effects
Urodynamics
/ drug effects
glucagon-like peptide-1
hemodynamics
renal afferent
sodium and water homeostasis
sympathetic nerve activity
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
pubmed:
8
8
2019
medline:
31
3
2020
entrez:
8
8
2019
Statut:
ppublish
Résumé
Glucagon-like peptide-1 (GLP-1), an incretin hormone, has diuretic and natriuretic effects. The present study was designed to explore the possible underlying mechanisms for the diuretic and natriuretic effects of GLP-1 via renal nerves in rats. Immunohistochemistry revealed that GLP-1 receptors were avidly expressed in the pelvic wall, the wall being adjacent to afferent renal nerves immunoreactive to calcitonin gene-related peptide, which is the dominant neurotransmitter for renal afferents. GLP-1 (3 μM) infused into the left renal pelvis increased ipsilateral afferent renal nerve activity (110.0 ± 15.6% of basal value). Intravenous infusion of GLP-1 (1 µg·kg
Identifiants
pubmed: 31390233
doi: 10.1152/ajprenal.00028.2019
pmc: PMC6843041
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Glucagon-Like Peptide 1
89750-14-1
Sodium
9NEZ333N27
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F1010-F1021Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL062222
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114663
Pays : United States
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