Effectiveness and Safety of Rivaroxaban 15 or 20 mg Versus Vitamin K Antagonists in Nonvalvular Atrial Fibrillation.
Administration, Oral
Aged
Aged, 80 and over
Anticoagulants
/ therapeutic use
Atrial Fibrillation
/ complications
Cohort Studies
Embolism
/ epidemiology
Factor Xa Inhibitors
/ therapeutic use
Female
Fibrinolytic Agents
/ therapeutic use
Hemorrhage
/ complications
Humans
Male
Rivaroxaban
/ therapeutic use
Stroke
/ drug therapy
Vitamin K
/ antagonists & inhibitors
Warfarin
/ therapeutic use
France
atrial fibrillation
humans
pharmacoepidemiology
rivaroxaban
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
9
8
2019
medline:
13
3
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
Background and Purpose- We compared the 1-year safety and effectiveness of rivaroxaban 15 mg (R15) or rivaroxaban 20 mg (R20) to vitamin K antagonists (VKAs) in patients with nonvalvular atrial fibrillation. Methods- New user cohort study of patients dispensed R15 or R20 versus VKA in 2013 or 2014 for nonvalvular atrial fibrillation, followed 1 year in the French Système National des Données de Santé (66 million people). R15 and R20 users were matched 1:1 with VKA users on sex, age, date of first drug dispensing, and high-dimensional propensity score. Hazard ratios (95% CIs) for stroke and systemic embolism, major bleeding, and death were computed using Cox proportional hazards or models by Fine and Gray during exposure. Results- In 31 171 matched R20 and VKA, mean age, 71; 62% men; 76% with CHA
Identifiants
pubmed: 31390972
doi: 10.1161/STROKEAHA.119.025824
pmc: PMC6727926
doi:
Substances chimiques
Anticoagulants
0
Factor Xa Inhibitors
0
Fibrinolytic Agents
0
Vitamin K
12001-79-5
Warfarin
5Q7ZVV76EI
Rivaroxaban
9NDF7JZ4M3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2469-2476Références
J Am Heart Assoc. 2018 Apr 13;7(8):
pubmed: 29654196
Arch Intern Med. 2007 Jan 8;167(1):68-73
pubmed: 17210880
Br J Clin Pharmacol. 2016 Mar;81(3):569-78
pubmed: 26493768
Int J Cardiol. 2018 Jun 15;261:78-83
pubmed: 29559181
Stat Med. 2009 Nov 10;28(25):3083-107
pubmed: 19757444
Lancet. 2005 Jan 1-7;365(9453):82-93
pubmed: 15639683
Stroke. 2017 Aug;48(8):2142-2149
pubmed: 28655814
J Am Heart Assoc. 2018 Apr 5;7(8):
pubmed: 29622587
Pharmacoepidemiol Drug Saf. 2019 Feb;28(2):194-200
pubmed: 30395375
Pharmacoepidemiol Drug Saf. 2012 Jan;21 Suppl 1:41-9
pubmed: 22262592
Thromb Res. 2018 May 17;167:113-118
pubmed: 29803981
Am J Epidemiol. 2011 Jun 15;173(12):1404-13
pubmed: 21602301
Br J Clin Pharmacol. 2017 Sep;83(9):2056-2065
pubmed: 28345154
Circulation. 2015 Sep 29;132(13):1252-60
pubmed: 26199338
Arch Intern Med. 1987 Sep;147(9):1561-4
pubmed: 3632164
Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):954-962
pubmed: 28544284
J Am Coll Cardiol. 2018 Jul 31;72(5):477-485
pubmed: 30049307
Int J Cardiol. 2018 Oct 1;268:113-119
pubmed: 29934230
Lancet Haematol. 2015 Apr;2(4):e150-9
pubmed: 26687957
Med Care. 2016 Feb;54(2):188-94
pubmed: 26683778
Eur J Clin Pharmacol. 2013 Mar;69(3):549-57
pubmed: 22763756
Eur Neurol. 2015;74(1-2):92-9
pubmed: 26337650
Am J Cardiol. 2017 Nov 15;120(10):1813-1819
pubmed: 28864318
J Am Coll Cardiol. 2017 Jun 13;69(23):2779-2790
pubmed: 28595692
Fundam Clin Pharmacol. 2015 Dec;29(6):586-91
pubmed: 26301735
J Thromb Haemost. 2011 Nov;9(11):2153-8
pubmed: 21920015
BMJ. 2004 Jul 3;329(7456):15-9
pubmed: 15231615
Stat Sci. 2010 Feb 1;25(1):1-21
pubmed: 20871802
BMJ. 2017 Feb 10;356:j510
pubmed: 28188243
Am Heart J. 2008 Nov;156(5):855-63, 863.e2
pubmed: 19061698
Epidemiology. 2009 Jul;20(4):512-22
pubmed: 19487948
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001927
pubmed: 16034869
Epidemiology. 2017 Mar;28(2):237-248
pubmed: 27779497
J Intern Med. 2018 Jan;283(1):45-55
pubmed: 28861925
N Engl J Med. 2011 Sep 8;365(10):883-91
pubmed: 21830957
Br J Clin Pharmacol. 2019 Feb;85(2):432-441
pubmed: 30423205
Pharmacotherapy. 2018 Jan;38(1):6-18
pubmed: 29028119
BMJ. 2016 Jun 16;353:i3189
pubmed: 27312796
J Am Heart Assoc. 2016 Jun 13;5(6):
pubmed: 27412905
Clin Pharmacol Ther. 2019 Jun;105(6):1439-1455
pubmed: 30499605
Lancet. 2014 Mar 15;383(9921):955-62
pubmed: 24315724
J Thromb Haemost. 2005 Apr;3(4):692-4
pubmed: 15842354