Female infertility: which role for obesity?
Journal
International journal of obesity supplements
ISSN: 2046-2166
Titre abrégé: Int J Obes Suppl
Pays: England
ID NLM: 101590890
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
entrez:
9
8
2019
pubmed:
9
8
2019
medline:
9
8
2019
Statut:
ppublish
Résumé
Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium functions, with a final alteration in oocyte maturation and endometrial epithelium receptivity. In addition, through the development of peripheral insulin resistance obesity produces a condition of functional hyperandrogenism and hyperestrogenism that contribute to produce anovulation and to reduce endometrial receptivity and, therefore participate to cause infertility. Weight loss is able to restore fertility in most cases, but there are no practical indications to guide the clinician to choice the best method among increased physical activity, diet, drugs, and bariatric surgery.
Identifiants
pubmed: 31391925
doi: 10.1038/s41367-019-0009-1
pii: 9
pmc: PMC6683114
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
65-72Déclaration de conflit d'intérêts
Conflict of interestAG is a consultant for Bayer. The remaining authors declare that they have no conflict of interest.
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