Endothelial to Mesenchymal Transition in the Cardiogenesis and Cardiovascular Diseases.
Endothelial to mesenchymal transition
TGF-β
cardiogenesis
cardiovascular disease
congenital heart diseases
Journal
Current cardiology reviews
ISSN: 1875-6557
Titre abrégé: Curr Cardiol Rev
Pays: United Arab Emirates
ID NLM: 101261935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
04
2019
revised:
05
07
2019
accepted:
09
07
2019
pubmed:
9
8
2019
medline:
20
2
2021
entrez:
9
8
2019
Statut:
ppublish
Résumé
Today, cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. Endothelial to mesenchymal transition (EndMT) does not only play a major role in the course of development but also contributes to several cardiovascular diseases in adulthood. EndMT is characterized by down-regulation of the endothelial proteins and highly up-regulated fibrotic specific genes and extracellular matrix-forming proteins. EndMT is also a transforming growth factor- β-driven (TGF-β) process in which endothelial cells lose their endothelial characteristics and acquire a mesenchymal phenotype with expression of α-smooth muscle actin (α-SMA), fibroblastspecific protein 1, etc. EndMT is a vital process during cardiac development, thus disrupted EndMT gives rise to the congenital heart diseases, namely septal defects and valve abnormalities. In this review, we have discussed the main signaling pathways and mechanisms participating in the process of EndMT such as TGF-β and Bone morphogenetic protein (BMP), Wnt#, and Notch signaling pathway and also studied the role of EndMT in physiological cardiovascular development and pathological conditions including myocardial infarction, pulmonary arterial hypertension, congenital heart defects, cardiac fibrosis, and atherosclerosis. As a perspective view, having a clear understanding of involving cellular and molecular mechanisms in EndMT and conducting Randomized controlled trials (RCTs) with a large number of samples for involving pharmacological agents may guide us into novel therapeutic approaches of congenital disorders and heart diseases.
Identifiants
pubmed: 31393254
pii: CCR-EPUB-100200
doi: 10.2174/1573403X15666190808100336
pmc: PMC7903503
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
306-314Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Circ Res. 2016 Nov 11;119(11):1215-1225
pubmed: 27750208
Oncotarget. 2016 May 24;7(21):31053-66
pubmed: 27105518
Dev Cell. 2015 Jan 26;32(2):181-90
pubmed: 25625207
Ann Thorac Surg. 2008 Jun;85(6):2090-8
pubmed: 18498827
Nat Med. 2007 Aug;13(8):952-61
pubmed: 17660828
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1679-89
pubmed: 23685555
Nature. 2016 Apr 7;532(7597):122-6
pubmed: 27027284
Biochim Biophys Acta. 2016 Apr;1862(4):733-740
pubmed: 26876948
Life Sci. 2017 Sep 1;184:95-102
pubmed: 28716564
Cell Mol Life Sci. 2013 Aug;70(16):2899-917
pubmed: 23161060
Pediatr Cardiol. 2009 Jul;30(5):643-50
pubmed: 19184573
Circ Res. 2009 Aug 28;105(5):408-21
pubmed: 19713546
PLoS One. 2016 Nov 11;11(11):e0166480
pubmed: 27835665
J Am Coll Cardiol. 2017 Sep 5;70(10):1232-1244
pubmed: 28859786
J Mol Med (Berl). 2015 Jul;93(7):735-48
pubmed: 25943780
Life Sci. 2016 Mar 1;148:1-8
pubmed: 26860892
Circulation. 2016 May 3;133(18):1783-94
pubmed: 27045138
J Thorac Cardiovasc Surg. 2014 Jul;148(1):245-53
pubmed: 24084286
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):303-8
pubmed: 25425619
Pediatr Cardiol. 2009 Jul;30(5):617-25
pubmed: 19277768
Lab Invest. 2017 Sep;97(9):1033-1046
pubmed: 28737766
J Am Coll Cardiol. 2014 Jun 24;63(24):2734-41
pubmed: 24681145
J Biol Chem. 2014 Jul 4;289(27):18681-92
pubmed: 24831012
Circulation. 2002 Apr 9;105(14):1672-8
pubmed: 11940546
Circulation. 2010 Dec 7;122(23):2419-29
pubmed: 21098445
Arthritis Res Ther. 2012 Aug 22;14(4):R194
pubmed: 22913887
Int J Mol Sci. 2016 May 18;17(5):
pubmed: 27213345
J Clin Invest. 2010 Oct;120(10):3493-507
pubmed: 20890042
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):e135-46
pubmed: 22962329
Eur Respir J. 2012 Feb;39(2):329-43
pubmed: 21737550
Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1055-63
pubmed: 26993222
J Clin Invest. 2017 Jan 3;127(1):383-401
pubmed: 27918308
Circ Res. 2016 May 13;118(10):1480-97
pubmed: 27056911
Trends Cardiovasc Med. 2013 Jul;23(5):135-42
pubmed: 23295082
Hypertension. 2014 Jun;63(6):1260-9
pubmed: 24614212
Cancer Res. 2015 Apr 1;75(7):1244-54
pubmed: 25634211
Biochim Biophys Acta. 2013 Apr;1833(4):917-22
pubmed: 23078978
Drug Des Devel Ther. 2015 Aug 11;9:4599-611
pubmed: 26316699
Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5
pubmed: 24632204
Nat Commun. 2016 Jun 24;7:11853
pubmed: 27340017
Development. 2013 Aug;140(16):3395-402
pubmed: 23863481
Sci Signal. 2014 Sep 23;7(344):ra90
pubmed: 25249657
Biomater Res. 2016 May 25;20:13
pubmed: 27226899
Cells Tissues Organs. 2007;185(1-3):146-56
pubmed: 17587820
Microvasc Res. 2016 Nov;108:48-63
pubmed: 27503671
Int J Mol Med. 2017 Aug;40(2):558-568
pubmed: 28656247
Exp Cell Res. 2013 May 15;319(9):1317-23
pubmed: 23291327
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 May;41(3):298-304
pubmed: 22723165
Biochem J. 2011 Aug 1;437(3):515-20
pubmed: 21585337
Nat Commun. 2017 Oct 12;8(1):895
pubmed: 29026072
Proc Am Thorac Soc. 2012 Jul;9(3):158-63
pubmed: 22802291
J Biol Chem. 2011 Apr 1;286(13):11803-13
pubmed: 21288908
J Clin Invest. 2014 Jul;124(7):2921-34
pubmed: 24937432
Cardiovasc Res. 2015 Dec 1;108(3):377-86
pubmed: 26084310
Cell Signal. 2017 Oct;38:26-38
pubmed: 28648944
J Clin Invest. 2009 Jul;119(7):1986-96
pubmed: 19509466
Dis Model Mech. 2011 Jul;4(4):469-83
pubmed: 21324930
PLoS One. 2016 May 13;11(5):e0155730
pubmed: 27176484
J Am Coll Cardiol. 2016 Apr 5;67(13):1556-1568
pubmed: 27150688
Int J Cardiol. 2014 Sep;176(1):99-109
pubmed: 25049013
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):205-217
pubmed: 28062508
Pediatr Cardiol. 2010 Apr;31(3):342-8
pubmed: 19967349
Dev Dyn. 2015 Oct;244(10):1259-75
pubmed: 26198058
Oncotarget. 2017 May 19;8(32):52995-53016
pubmed: 28881789
Nephrol Dial Transplant. 2010 May;25(5):1688-96
pubmed: 20150166
Circulation. 2010 Jun 8;121(22):2407-18
pubmed: 20497976
Biomol Ther (Seoul). 2016 Mar 1;24(2):132-9
pubmed: 26869523
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):121-30
pubmed: 23104848
PLoS One. 2014 Sep 12;9(9):e107175
pubmed: 25215881
J Biol Chem. 2015 Jul 3;290(27):16653-64
pubmed: 25971970
Dev Biol. 2016 May 15;413(2):188-98
pubmed: 26994311
Circ Res. 2008 May 23;102(10):1169-81
pubmed: 18497317
Zhonghua Yi Xue Za Zhi. 2017 Mar 21;97(11):869-873
pubmed: 28355745
J Biol Chem. 2006 Oct 13;281(41):30979-89
pubmed: 16920707
Cell Signal. 2012 Jan;24(1):247-56
pubmed: 21945156
J Cell Commun Signal. 2019 Jun;13(2):255-267
pubmed: 30073629
Int J Cardiol. 2013 Jan 10;162(2):92-9
pubmed: 21704391
Sci Rep. 2017 Jun 13;7(1):3375
pubmed: 28611395
J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S20-S31
pubmed: 19555855
J Biochem. 2013 Jun;153(6):493-5
pubmed: 23613024
Nat Commun. 2016 Aug 12;7:12422
pubmed: 27516371
Pediatr Cardiol. 2010 Apr;31(3):363-70
pubmed: 20033145
IUBMB Life. 2012 Sep;64(9):717-23
pubmed: 22730243
EMBO Mol Med. 2015 Nov 26;8(1):6-24
pubmed: 26612856
Dev Dyn. 2010 Dec;239(12):3182-91
pubmed: 20981833
Niger J Physiol Sci. 2018 Jun 30;33(1):9-15
pubmed: 30091727
Development. 2012 Dec 1;139(23):4449-60
pubmed: 23095891