Updated Clinical Outcomes of Hematopoietic Stem Cell Transplantation Using Myeloablative Total Body Irradiation with Ovarian Shielding to Preserve Fertility.
Fertility
Hematopoietic stem cell transplantation
Ovarian shielding
Total body irradiation
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
10
06
2019
revised:
25
07
2019
accepted:
26
07
2019
pubmed:
9
8
2019
medline:
9
9
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
Myeloablative conditioning regimens are associated with severe gonadal toxicity. To preserve ovarian function, we have been investigating ovarian shielding during total body irradiation (TBI) with a myeloablative dose. In this report, we update the clinical outcomes. Female patients with standard-risk hematologic diseases, aged 40 years or younger, who desired to have children, were included (n = 19). The conditioning regimen consisted of TBI at 12 Gy with ovarian shielding and cyclophosphamide (120 mg/kg) or cytarabine (24 g/m
Identifiants
pubmed: 31394267
pii: S1083-8791(19)30511-7
doi: 10.1016/j.bbmt.2019.07.039
pii:
doi:
Substances chimiques
Anti-Mullerian Hormone
80497-65-0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2461-2467Informations de copyright
Copyright © 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.