Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis.
NAMPT
TLR4
bone
cartilage
catabolism
inflammation
metabolic alterations
osteoarthritis
osteoporosis
visfatin
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Aug 2019
07 Aug 2019
Historique:
received:
20
07
2019
revised:
29
07
2019
accepted:
04
08
2019
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
10
8
2019
Statut:
epublish
Résumé
Musculoskeletal pathologies (MSPs) such as osteoarthritis (OA) and osteoporosis (OP), are a set of disorders that cause severe pain, motion difficulties, and even permanent disability. In developed countries, the current incidence of MSPs reaches about one in four adults and keeps escalating as a consequence of aging and sedentarism. Interestingly, OA and OP have been closely related to similar risk factors, including aging, metabolic alterations, and inflammation. Visfatin, an adipokine with an inflammatory and catabolic profile, has been associated with several OA and OP metabolic risk factors, such as obesity, insulin resistance, and type II diabetes. Furthermore, visfatin has been associated with the innate immune receptor toll-like receptor 4 (TLR4), which plays a key role in cartilage and bone inflammatory and catabolic responses. Moreover, visfatin has been related to several OA and OP pathologic features. The aim of this work is to bring together basic and clinical data regarding the common role of visfatin in these pathologies and their major shared risk factors. Finally, we discuss the pitfalls of visfatin as a potential biomarker and therapeutic target in both pathologies.
Identifiants
pubmed: 31394795
pii: jcm8081178
doi: 10.3390/jcm8081178
pmc: PMC6723538
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI16/01870, CP15/00007, PI14/00016, and PI17/00409
Organisme : RETICS
ID : RD16/0012/0014
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : Number 734899
Organisme : Mutua Madrileña Fundation
ID : MMA 2018
Organisme : FEDER
ID : FEDER 2019
Organisme : Ministry of Science, Innovation and Universities
ID : FPU 2018
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