CSCs in Breast Cancer-One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs.
NF-κB
Wnt
YAP
breast cancer
cancer stem cell
epithelial
hypoxia
mesenchymal
triple negative breast cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Aug 2019
07 Aug 2019
Historique:
received:
16
06
2019
revised:
02
08
2019
accepted:
04
08
2019
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
10
8
2019
Statut:
epublish
Résumé
Unlike other breast cancer subtypes, triple-negative breast cancer (TNBC) has no specific targets and is characterized as one of the most aggressive subtypes of breast cancer that disproportionately accounts for the majority of breast cancer-related deaths. Current conventional chemotherapeutics target the bulk tumor population, but not the cancer stem cells (CSCs) that are capable of initiating new tumors to cause disease relapse. Recent studies have identified distinct epithelial-like (E) ALDH
Identifiants
pubmed: 31394796
pii: cancers11081128
doi: 10.3390/cancers11081128
pmc: PMC6721464
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2019-05220
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