Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.
Biological Markers
Biomarker
Depression
ECoG
Treatment Refractory Epilepsy
Journal
The Journal of neuropsychiatry and clinical neurosciences
ISSN: 1545-7222
Titre abrégé: J Neuropsychiatry Clin Neurosci
Pays: United States
ID NLM: 8911344
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
10
8
2019
medline:
18
11
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
Adult patients with epilepsy have an increased prevalence of major depressive disorder (MDD). Intracranial EEG (iEEG) captured during extended inpatient monitoring of patients with treatment-resistant epilepsy offers a particularly promising method to study MDD networks in epilepsy. The authors used 24 hours of resting-state iEEG to examine the neural activity patterns within corticolimbic structures that reflected the presence of depressive symptoms in 13 adults with medication-refractory epilepsy. Principal component analysis was performed on the z-scored mean relative power in five standard frequency bands averaged across electrodes within a region. Principal component 3 was a statistically significant predictor of the presence of depressive symptoms (R These finding suggest, for the first time, that neural features across circuits involved in epilepsy may distinguish patients who have depressive symptoms from those who do not. Larger studies are required to validate these findings and to assess their diagnostic utility in MDD.
Identifiants
pubmed: 31394989
doi: 10.1176/appi.neuropsych.19030081
pmc: PMC7429560
mid: NIHMS1610259
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-190Subventions
Organisme : NINDS NIH HHS
ID : K23 NS110962
Pays : United States
Références
Biol Psychiatry. 1990 Apr 1;27(7):757-80
pubmed: 2183880
J Abnorm Psychol. 1991 Nov;100(4):535-45
pubmed: 1757667
Cereb Cortex. 2018 Apr 1;28(4):1383-1395
pubmed: 29300840
Neuropsychobiology. 2000;41(1):31-7
pubmed: 10629433
Psychiatry Res. 2011 Jun 30;192(3):188-94
pubmed: 21546222
Neuropsychopharmacology. 2011 Jan;36(1):183-206
pubmed: 20861828
Epilepsia. 2012 Oct;53(10):1705-12
pubmed: 22881990
J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):53-8
pubmed: 10601402
Epilepsy Behav. 2014 Jul;36:138-43
pubmed: 24926942
Semin Clin Neuropsychiatry. 2001 Apr;6(2):113-20
pubmed: 11296311
Neuroimage. 2015 Jan 15;105:493-506
pubmed: 25463459
Biol Psychiatry. 2008 Apr 1;63(7):656-62
pubmed: 17949689
Psychiatry Investig. 2017 Sep;14(5):708-711
pubmed: 29042900
Neurology. 2009 Mar 3;72(9):793-9
pubmed: 19255406
Psychiatry Res. 2009 Sep 30;169(2):132-8
pubmed: 19709754
Sci Rep. 2016 Oct 06;6:34824
pubmed: 27708381
Depress Anxiety. 2017 Jan;34(1):9-24
pubmed: 27653321
Psychiatry Res. 2000 Apr 10;98(2):71-91
pubmed: 10762734
Hum Brain Mapp. 2007 Mar;28(3):247-61
pubmed: 16779797
Psychopharmacology (Berl). 2006 Sep;188(1):42-52
pubmed: 16850117
Magn Reson Med. 2009 Dec;62(6):1619-28
pubmed: 19859933
Neurology. 2004 Jan 27;62(2):258-61
pubmed: 14745064
Psychiatry Res. 2001 Apr 10;106(2):123-40
pubmed: 11306251
Eur Neuropsychopharmacol. 2010 Jul;20(7):459-66
pubmed: 20421161
Transl Psychiatry. 2017 Jul 4;7(7):e1165
pubmed: 28675389
Brain Topogr. 2008 Dec;21(2):138-46
pubmed: 18958615
JAMA Psychiatry. 2015 Jun;72(6):603-11
pubmed: 25785575
J Abnorm Psychol. 1990 Feb;99(1):22-31
pubmed: 2307762
Cell. 2018 Nov 29;175(6):1688-1700.e14
pubmed: 30415834
Psychiatry Res. 2009 Sep 30;169(2):124-31
pubmed: 19712979
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Am J Psychiatry. 2001 Mar;158(3):405-15
pubmed: 11229981
J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):903-9
pubmed: 22764263
Eur Arch Psychiatry Clin Neurosci. 2015 Feb;265(1):73-82
pubmed: 24848366
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Neuroimage Clin. 2016 Jul 27;12:320-31
pubmed: 27551669
JAMA Psychiatry. 2018 Jun 1;75(6):547-554
pubmed: 29641834
Radiology. 2014 Mar;270(3):842-8
pubmed: 24475828
Clin EEG Neurosci. 2015 Apr;46(2):73-80
pubmed: 24711613
PLoS One. 2012;7(2):e32508
pubmed: 22384265