The role of H3K79 methylation in transcription and the DNA damage response.
Journal
Mutation research. Reviews in mutation research
ISSN: 1388-2139
Titre abrégé: Mutat Res Rev Mutat Res
Pays: Netherlands
ID NLM: 101632211
Informations de publication
Date de publication:
Historique:
received:
10
05
2017
revised:
19
10
2017
accepted:
15
11
2017
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
3
3
2020
Statut:
ppublish
Résumé
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.
Identifiants
pubmed: 31395348
pii: S1383-5742(17)30054-6
doi: 10.1016/j.mrrev.2017.11.001
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
48-54Informations de copyright
Copyright © 2017 Elsevier B.V. All rights reserved.