Does Variant Histology Change Management of Non-muscle-invasive Bladder Cancer?
Bacillus Calmette-Guérin
ERBB2
HER2
Micropapillary differentiation
Radical cystectomy
Variant histology
Journal
European urology oncology
ISSN: 2588-9311
Titre abrégé: Eur Urol Oncol
Pays: Netherlands
ID NLM: 101724904
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
25
03
2019
revised:
31
05
2019
accepted:
14
06
2019
pubmed:
10
8
2019
medline:
2
2
2022
entrez:
10
8
2019
Statut:
ppublish
Résumé
A 52-yr-old man, 35 pack-year smoker, is diagnosed with two non-muscle-invasive urothelial tumors, pTa and pT1, the former upstaged to pT1 by a reference pathologist. Two possible treatment strategies include intravesical bacillus Calmette-Guérin (BCG) and/or primary or rescue cystectomy. The importance or even accurate existence of "variant histology" is put into perspective, and whether the reference pathologist's diagnosis of a micropapillary variant requires a real change in treatment strategy is considered. PATIENT SUMMARY: The reference urologist diagnosed two small bladder tumors as two different depths of infiltration: one as pTa and the other (slightly more severe) as pT1. Suspecting a variant, the reference urologist referred to a second pathologist, who upstaged the less severe tumor to T1, with both defined as micropapillary cancer. This presentation discusses removal of the bladder versus a trial of treatment with bladder preservation.
Identifiants
pubmed: 31395481
pii: S2588-9311(19)30093-8
doi: 10.1016/j.euo.2019.06.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
510-514Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.