Alfaxalone total intravenous anaesthesia in dogs: pharmacokinetics, cardiovascular data and recovery characteristics.
TIVA
alfaxalone
cardiovascular
neurosteroids
pharmacokinetics
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
23
11
2017
revised:
14
03
2019
accepted:
24
04
2019
pubmed:
10
8
2019
medline:
7
1
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
To evaluate the cardiovascular effects, pharmacokinetic (PK) data and recovery characteristics of an alfaxalone constant rate infusion (CRI) of different duration in dogs at manufacturer's recommended dose rate. Experimental, prospective, randomized, crossover study. Six intact female Beagles. Following an intravenous alfaxalone bolus (3 mg kg No significant difference was noted between protocols for any PK parameter. Volume of distribution at steady state (935.74 ± 170.25 versus 1119.15 ± 190.65 mL kg PK data were similar between long and short infusions of alfaxalone at the manufacturer's recommended dose, with acceptable cardiovascular conditions. Nevertheless, both protocols resulted in a superficial plane of general anaesthesia with poor recovery characteristics.
Identifiants
pubmed: 31395484
pii: S1467-2987(19)30136-9
doi: 10.1016/j.vaa.2019.04.014
pii:
doi:
Substances chimiques
Anesthetics, Intravenous
0
Pregnanediones
0
alphaxalone
BD07M97B2A
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
605-612Informations de copyright
Copyright © 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.