Effects of a neurodevelopmental genes based polygenic risk score for schizophrenia and single gene variants on brain structure in non-clinical subjects: A preliminary report.
Cortical thickness
Gyrification
Neurodevelopment
Polygenic risk score
Schizophrenia
Voxel-based morphometry
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
12
12
2018
revised:
27
05
2019
accepted:
30
07
2019
pubmed:
10
8
2019
medline:
6
10
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
We tested whether a polygenic risk score integrating the effects of genes affecting neurodevelopment is associated to brain structural variation in healthy subjects. We acquired magnetic resonance imaging and genetic data of 167 healthy adults and computed a neurodevelopmental polygenic risk score (nPRS). We correlated the nPRS with local gyrification, cortical thickness and grey matter density and explored effects of single nucleotide polymorphisms included in the score. We did not find significant correlations of this nPRS with either measure. Individuals with the risk allele at rs11139497 show increases in cortical thickness (p < 0.05, FWE corrected) of the left superior temporal gyrus.
Identifiants
pubmed: 31395486
pii: S0920-9964(19)30341-X
doi: 10.1016/j.schres.2019.07.061
pii:
doi:
Substances chimiques
Co-Repressor Proteins
0
TLE1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-228Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.