The effect of epidermal growth factor on the pseudo-healing of traumatic tympanic membrane perforations.
Epidermal growth factor
Tympanic membrane rupture
Wound healing
Wounds and injuries
Journal
Brazilian journal of otorhinolaryngology
ISSN: 1808-8686
Titre abrégé: Braz J Otorhinolaryngol
Pays: Brazil
ID NLM: 101207337
Informations de publication
Date de publication:
Historique:
received:
27
03
2019
revised:
28
04
2019
accepted:
22
06
2019
pubmed:
10
8
2019
medline:
17
2
2021
entrez:
10
8
2019
Statut:
ppublish
Résumé
Traumatic tympanic membrane perforations tend to heal spontaneously. However, in this study, several perforations exhibited abnormal healing, where the morphology of healing tympanic membranes differed from that of non-perforated tympanic membranes. Pseudo-healing of the tympanic membrane was characterized by the accumulation of thickened tissue in the perforated area. The purpose of this study was to evaluate the utility of epidermal growth factor in cases showing pseudo-healing of traumatic tympanic membrane perforations. A total of 26 traumatic tympanic membrane perforations showing pseudo-healing were included in this study. In all cases, tissue that accumulated in the perforated area was removed, which subsequently caused a new perforation to form. An epidermal growth factor solution was applied to the tympanic membrane once daily to keep the tympanic membrane moist. Closure rates and times were evaluated at 6 months. During the 6 months follow-up period, two patients were lost. Of the remaining 24 patients, the closure rate was 100% (24/24) and the closure time was 6.1 ± 2.3 days (range: 3-12 days). The morphology of the healed tympanic membrane was not significantly different from that of the remnant tympanic membrane. Pseudo-healing of traumatic tympanic membrane perforations affects sound conduction. This can be associated with various symptoms, including tinnitus, aural fullness, and ear discomfort. The excision of excessive epithelial tissue and topical application of epidermal growth factor can correct the pseudo-healing of traumatic tympanic membrane perforations.
Identifiants
pubmed: 31395492
pii: S1808-8694(19)30080-1
doi: 10.1016/j.bjorl.2019.06.011
pmc: PMC9422542
pii:
doi:
Substances chimiques
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-58Informations de copyright
Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.
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