Preponderance of
CTLA-4
CTLA4
abatacept
autoimmune hepatitis
de novo variant
ipilimumab
juvenile rheumatoid arthritis (JRA)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
03
2019
accepted:
20
06
2019
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
11
11
2020
Statut:
epublish
Résumé
One of the primary targets of immune checkpoint inhibition is the negative immune regulatory molecule CTLA-4. Immune-related adverse events are commonly observed following CTLA-4 inhibition in melanoma treatment, and a spectrum of these conditions are also observed in individuals with germline haploinsufficiency of
Identifiants
pubmed: 31396201
doi: 10.3389/fimmu.2019.01544
pmc: PMC6664875
doi:
Substances chimiques
Antirheumatic Agents
0
CTLA-4 Antigen
0
CTLA4 protein, human
0
Abatacept
7D0YB67S97
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1544Références
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