Osteoglycin and Bone-a Systematic Review.
Bone
Bone turnover
Insulin resistance
Osteoglycin
Journal
Current osteoporosis reports
ISSN: 1544-2241
Titre abrégé: Curr Osteoporos Rep
Pays: United States
ID NLM: 101176492
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
10
8
2019
medline:
29
9
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
Bone turnover is a regulated process. Osteoglycin is suggested to have an important impact on bone function but may also affect cardiovascular and metabolic functions. This review investigates the action of osteoglycin in bone as well as its potential endocrine effects. Osteoglycin is expressed by several tissues including bone and muscle. Some studies suggest that osteoglycin increases osteoblast differentiation whereas others suggest that osteoglycin decreases osteoblast differentiation. Thus, findings on the influence of osteoglycin in bone are conflicting. A recent study found increased bone mass in osteoglycin deficient mice. Another study reported that osteoglycin is a marker of low bone mineral density and vertebral fractures in women with type 2 diabetes. Furthermore, clinical studies link osteoglycin to insulin resistance and cardiovascular disease. Osteoglycin may be a novel marker of a muscle, pancreatic, and bone axis. However, current evidence is limited and further research investigating osteoglycin in both a pre-clinical and a clinical setting is needed.
Identifiants
pubmed: 31396918
doi: 10.1007/s11914-019-00523-z
pii: 10.1007/s11914-019-00523-z
doi:
Substances chimiques
Biomarkers
0
Intercellular Signaling Peptides and Proteins
0
OGN protein, human
0
Ogn protein, mouse
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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