The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases.
Guillaine-Barre syndrome
epilepsy
glia
glioblastoma
node of Ranvier
protease activated receptor 1
protease nexin 1
synapse
thrombin
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
10
8
2019
Statut:
ppublish
Résumé
The neuro-glial interface extends far beyond mechanical support alone and includes interactions throu-gh coagulation cascade proteins. Here, we systematically review the evidence indicating that synaptic and node of Ranvier glia cell components modulate synaptic transmission and axonal conduction by a coagulation cascade protein system, leading us to propose the concept of the neuro-glial coagulonome. In the peripheral nervous system, the main thrombin receptor protease activated receptor 1 (PAR1) is located on the Schwann microvilli at the node of Ranvier and at the neuromuscular junction. PAR1 activation effects can be both neuroprotective or harmful, depending on thrombin activity levels. Low physiological levels of thrombin induce neuroprotective effects in the Schwann cells which are mediated by the endothelial protein C receptor. High levels of thrombin induce conduction deficits, as found in experimental autoimmune neuritis, the animal model for Guillaine-Barre syndrome. In the central nervous system, PAR1 is located on the peri-synaptic astrocyte end-feet. Its activation by high thrombin levels is involved in the pathology of primary inflammatory brain diseases such as multiple sclerosis, as well as in other central nervous system insults, including trauma, neoplasms, epilepsy and vascular injury. Following activation of PAR1 by high thrombin levels the seizure threshold is lowered. On the other hand, PAR1 activation by lower levels of thrombin in the central nervous system protects against a future ischemic insult. This review presents the known structure and function of the neuro-glial coagulonome, focusing on coagulation, thrombin and PAR1 in a pathway which may be either physiological (neuroprotective) or detrimental in peripheral nervous system and central nervous system diseases. Understanding the neuro-glial coagulonome may open opportunities for novel pharmacological interventions in neurological diseases.
Identifiants
pubmed: 31397331
pii: NeuralRegenRes_2019_14_12_2043_262568
doi: 10.4103/1673-5374.262568
pmc: PMC6788244
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2043-2053Déclaration de conflit d'intérêts
None
Références
J Biol Chem. 2000 Sep 29;275(39):29955-9
pubmed: 10893407
J Neurosci Res. 2007 Mar;85(4):748-56
pubmed: 17265467
FASEB J. 1999 Mar;13(3):533-43
pubmed: 10064620
Circ Res. 2007 Feb 2;100(2):155-7
pubmed: 17272817
Neurosci Lett. 1991 Jul 8;128(1):42-6
pubmed: 1717897
PLoS One. 2017 Nov 28;12(11):e0188524
pubmed: 29182653
J Neurosci. 1997 Jun 15;17(12):4688-99
pubmed: 9169529
Cochrane Database Syst Rev. 2013 Apr 30;(4):CD007415
pubmed: 23633341
J Neurochem. 2002 Feb;80(4):655-66
pubmed: 11841573
J Neurooncol. 2017 Sep;134(3):479-485
pubmed: 28271281
J Neurochem. 2015 Dec;135(6):1140-8
pubmed: 26390857
Neurol Res. 2014 Aug;36(8):709-21
pubmed: 24620969
Mol Cell Neurosci. 2017 Mar;79:23-33
pubmed: 28064059
Int Rev Cytol. 2001;211:153-77
pubmed: 11597003
J Neurosci Res. 2005 Feb 1;79(3):351-9
pubmed: 15605378
J Neurosurg Spine. 2017 Apr;26(4):532-541
pubmed: 28059686
Front Cell Neurosci. 2013 Mar 05;7:19
pubmed: 23467310
J Neurosurg. 1997 Jul;87(1):73-8
pubmed: 9202268
J Mol Neurosci. 2019 Apr;67(4):589-594
pubmed: 30684238
J Neurochem. 2011 Nov;119(3):460-73
pubmed: 21854391
Neuro Oncol. 2016 Oct 1;18(suppl_5):v1-v75
pubmed: 28475809
J Neurobiol. 1999 Feb 15;38(3):369-81
pubmed: 10022579
Hippocampus. 2014 Aug;24(8):1030-8
pubmed: 24753100
Front Neurol. 2019 Feb 05;10:59
pubmed: 30804878
Nat Rev Immunol. 2015 Sep 15;15(9):545-58
pubmed: 26250739
Neurobiol Dis. 2013 Feb;50:171-8
pubmed: 23103417
J Neurosci. 2000 Jun 15;20(12):4582-95
pubmed: 10844028
Neuroscience. 2016 Dec 17;339:587-598
pubmed: 27771530
J Cell Physiol. 1991 Apr;147(1):76-86
pubmed: 2037625
Neural Plast. 2018 Jun 19;2018:7692182
pubmed: 30018633
Oncol Rep. 2014 Feb;31(2):679-86
pubmed: 24297570
Curr Opin Pharmacol. 2001 Dec;1(6):575-82
pubmed: 11757812
Thromb Haemost. 2001 Jul;86(1):51-6
pubmed: 11487041
J Mol Neurosci. 2019 Feb;67(2):227-234
pubmed: 30515700
J Neurochem. 1995 Feb;64(2):583-91
pubmed: 7830051
Neurology. 2018 Apr 24;90(17):777-788
pubmed: 29686116
Stroke. 2012 Sep;43(9):2476-82
pubmed: 22811450
J Neurosci Res. 2018 Aug;96(8):1406-1411
pubmed: 29761540
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Neurosci Lett. 2002 Aug 30;329(2):181-4
pubmed: 12165407
J Neurosci Res. 2003 Jul 1;73(1):10-21
pubmed: 12815704
FASEB J. 2019 Apr;33(4):4703-4715
pubmed: 30592632
J Neurotrauma. 2016 Oct 15;33(20):1848-1854
pubmed: 26537880
Front Neurol. 2017 Apr 10;8:138
pubmed: 28443061
Cond Med. 2018 Feb;1(2):57-63
pubmed: 30123875
J Neurochem. 1996 Nov;67(5):2188-99
pubmed: 8863530
Semin Thromb Hemost. 2013 Nov;39(8):876-80
pubmed: 24108468
J Neurosci. 2008 Jan 16;28(3):732-6
pubmed: 18199772
Pain. 2018 Jul;159(7):1257-1267
pubmed: 29554016
Iran J Basic Med Sci. 2018 Aug;21(8):832-841
pubmed: 30186571
Cancer Med. 2016 Oct;5(10):2886-2898
pubmed: 27600331
Front Cell Neurosci. 2015 Apr 21;9:151
pubmed: 25954157
Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86
pubmed: 30445539
Neurogastroenterol Motil. 2009 Nov;21(11):1218-21
pubmed: 19566587
Biochim Biophys Acta. 2013 Nov;1834(11):2454-61
pubmed: 23603790
Acta Neurochir Suppl. 2016;121:355-60
pubmed: 26463974
Biol Chem. 2003 Feb;384(2):193-202
pubmed: 12675511
Brain Res. 2005 Apr 18;1041(2):205-11
pubmed: 15829229
Mayo Clin Proc. 2017 Mar;92(3):467-479
pubmed: 28259232
Neuron Glia Biol. 2010 Aug;6(3):137-9
pubmed: 23164153
J Neurosci. 2015 Jan 14;35(2):776-85
pubmed: 25589770
Rev Neurol (Paris). 2016 Jan;172(1):3-13
pubmed: 26718593
Neuroreport. 2001 Mar 26;12(4):715-9
pubmed: 11277570
Exp Neurol. 2013 Sep;247:595-604
pubmed: 23454608
Mol Neurobiol. 2017 Aug;54(6):4379-4389
pubmed: 27344331
Brain. 2011 Nov;134(Pt 11):3209-21
pubmed: 22021895
Neurochem Res. 2015 Nov;40(11):2220-9
pubmed: 26342829
Eur J Neurosci. 2012 Aug;36(3):2293-301
pubmed: 22616675
J Mol Neurosci. 2014 May;53(1):87-95
pubmed: 24352712
Neuroscience. 2016 Feb 9;314:189-99
pubmed: 26642807
Biol Psychiatry. 2009 Feb 15;65(4):304-12
pubmed: 18801476
Brain Res. 2000 Jun 9;867(1-2):173-9
pubmed: 10837811
Mediators Inflamm. 2015;2015:831059
pubmed: 26604433
J Cell Physiol. 2017 Mar;232(3):482-485
pubmed: 27458694
Glia. 2015 May;63(5):846-59
pubmed: 25628003
Neuropharmacology. 2009;56 Suppl 1:83-90
pubmed: 18647612
Sci Rep. 2015 Jan 21;5:7912
pubmed: 25604482
Int J Mol Sci. 2013 Aug 14;14(8):16719-31
pubmed: 23949634
Front Neurol. 2018 Dec 17;9:1087
pubmed: 30619047
J Mol Neurosci. 2015 Jul;56(3):644-51
pubmed: 25691153
Nature. 2008 Feb 28;451(7182):1076-81
pubmed: 18278032
Nat Rev Neurosci. 2013 Feb;14(2):128-42
pubmed: 23329160
P T. 2012 Mar;37(3):175-84
pubmed: 22605909
Neurology. 2009 Sep 8;73(10):768-74
pubmed: 19738171
Neurobiol Dis. 2016 Sep;93:226-42
pubmed: 27145117
J Neurosci. 2017 Nov 29;37(48):11758-11768
pubmed: 29089436
J Neurosci Res. 2017 Oct;95(10):2080-2085
pubmed: 28316070
Nat Rev Neurol. 2014 Aug;10(8):469-82
pubmed: 25023340
Neuroreport. 2007 Apr 16;18(6):581-4
pubmed: 17413661
Brain Behav Immun. 2015 Aug;48:195-204
pubmed: 25882911
Neuroscience. 2018 Feb 10;371:445-454
pubmed: 29292076
J Neurosci. 2007 Apr 4;27(14):3677-85
pubmed: 17409231
Nature. 2000 Apr 6;404(6778):609-13
pubmed: 10766244
PLoS Genet. 2019 Mar 14;15(3):e1007948
pubmed: 30870413
Brain. 2008 Apr;131(Pt 4):1113-22
pubmed: 18299297
Mol Med. 2000 May;6(5):410-29
pubmed: 10952021
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11832-11837
pubmed: 30373833
Curr Med Chem. 2008;15(17):1697-705
pubmed: 18673219
Front Neurol. 2019 Jan 04;9:1139
pubmed: 30662428
JAMA Oncol. 2016 Nov 1;2(11):1460-1469
pubmed: 27310651
J Neurosci. 2008 Nov 26;28(48):12788-97
pubmed: 19036971