Risk Factors and Outcomes of Recurrent Pregnancy Loss in Japan.
factor XII deficiency
pregnancy outcomes
protein S deficiency
recurrent pregnancy loss
risk factors
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
22
03
2019
accepted:
13
07
2019
pubmed:
10
8
2019
medline:
3
3
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
To clarify the risk factors and pregnancy outcomes for each risk factor of recurrent pregnancy loss (RPL) in Japan. Using a prospective RPL database collected from 16 facilities in Japan, the prevalence of risk factors for RPL, their treatments and pregnancy outcomes were examined. Of 6663 patients registered in our database, 5708 patients had RPL. All examinations for risk factors were performed for 1340 patients (23.5%). The prevalences of positive antiphospholipid antibodies (aPL), malformation of the uterus, thyroid dysfunction, parental karyotype abnormality, factor XII deficiency, protein S deficiency and unknown risk factors were 8.7%, 7.9%, 9.5%, 3.7%, 7.6%, 4.3% and 65.1%, respectively. Although factor XII deficiency and protein S deficiency are not recognized as risk factors for RPL in general, low-dose aspirin (LDA) or unfractionated heparin + LDA therapy improved live birth rates. In transiently aPL-positive patients, the live birth rate with LDA therapy was similar to that with heparin + LDA. For unknown risk factors of RPL, the live birth rate in normal fetal karyotype in the none treatment group was similar to that in all other treatments group (81.3% vs 86.0%). Of 5708 RPL patients, pregnancy outcomes were known for 2261 patients and 1697 patients (75.1%) had at least one live birth. The risk factors and pregnancy outcomes for each risk factor of RPL are useful for clinicians and patients. Factor XII deficiency and protein S deficiency may be risk factors of RPL.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1997-2006Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP18gk0110018h0003
Organisme : Japan Society for the Promotion of Science
ID : JP15H04980
Informations de copyright
© 2019 Japan Society of Obstetrics and Gynecology.
Références
Practice Committee of American Society for Reproductive M. Definitions of infertility and recurrent pregnancy loss: A committee opinion. Fertil Steril 2013; 99: 63.
Bender Atik R, Christiansen OB, Elson J et al. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open 2018; 2018 https://doi.org/10.1093/hropen/hoy004.
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: Population based register linkage study. BMJ 2000; 320: 1708-1712.
Saito H, Jwa SC, Kuwahara A et al. Assisted reproductive technology in Japan: A summary report for 2015 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology. Reprod Med Biol 2018; 17: 20-28.
Kojima T. Congenital anticoagulant deficiency (antithrombin, protein C, protein S deficiency). Jpn J Thromb Hemast 2009; 20: 484-486.
Dendrinos S, Deliveliotou A, Anastasiou A, Creatsas GK. Role of coagulation factor XII in unexplained recurrent abortions in the Greek population. J Reprod Med 2014; 59: 56-62.
Robertson L, Wu O, Langhorne P et al. Thrombophilia in pregnancy: A systematic review. Br J Haematol 2006; 132: 171-196.
Group EEPGD. Recurrent Pregnancy Loss. Guideline of the European Society of Human Reproduction and Embryology, 2017.
Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: A critical appraisal. Hum Reprod Update 2008; 14: 415-429.
Sugiura-Ogasawara M, Lin BL, Aoki K et al. Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies? J Obstet Gynaecol 2015; 35: 155-158.
Pang LH, Li MJ, Li M, Xu H, Wei ZL. Not every subseptate uterus requires surgical correction to reduce poor reproductive outcome. Int J Gynaecol Obstet 2011; 115: 260-263.
Rao VR, Lakshmi A, Sadhnani MD. Prevalence of hypothyroidism in recurrent pregnancy loss in first trimester. Indian J Med Sci 2008; 62: 357-361.
Bernardi LA, Cohen RN, Stephenson MD. Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertil Steril 2013; 100: 1326-1331.
Lata K, Dutta P, Sridhar S et al. Thyroid autoimmunity and obstetric outcomes in women with recurrent miscarriage: A case-control study. Endocr Connect 2013; 2: 118-124.
Flynn H, Yan J, Saravelos SH, Li TC. Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages. J Obstet Gynaecol Res 2014; 40: 109-116.
Sugiura-Ogasawara M, Aoki K, Fujii T et al. Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. J Hum Genet 2008; 53: 622-628.
Ozawa N, Maruyama T, Nagashima T et al. Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss. Fertil Steril 2008; 90: 1301-1304.
Gomez-Puerta JA, Cervera R. Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun 2014; 48-49: 20-25.
Sugiura-Ogasawara M, Ozaki Y, Nakanishi T, Sato T, Suzumori N, Kumagai K. Occasional antiphospholipid antibody positive patients with recurrent pregnancy loss also merit aspirin therapy: A retrospective cohort-control study. Am J Reprod Immunol 2008; 59: 235-241.
Braulke I, Pruggmayer M, Melloh P, Hinney B, Kostering H, Gunther E. Factor XII (Hageman) deficiency in women with habitual abortion: New subpopulation of recurrent aborters? Fertil Steril 1993; 59: 98-101.
Gris JC, Ripart-Neveu S, Maugard C et al. Respective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages. The Nimes obstetricians and haematologists (NOHA) study. Thromb Haemost 1997; 77: 1096-1103.
Matsuura T, Kobayashi T, Asahina T, Kanayama N, Terao T. Is factor XII deficiency related to recurrent miscarriage? Semin Thromb Hemost 2001; 27: 115-120.
Iwaki T, Castellino FJ. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost 2006; 95: 1003-1010.
Jones DW, MacKie IJ, Gallimore MJ, Winter M. Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome. Br J Haematol 2001; 113: 550-552.
Sato Y, Sugi T, Sakai R. Autoantibodies to factor XII and Kininogen-dependent Antiphosphatidylethanolamine antibodies in patients with recurrent pregnancy loss augment platelet aggregation. Am J Reprod Immunol 2015; 74: 279-289.
Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: A meta-analysis. Lancet 2003; 361: 901-908.
Paidas MJ, Ku DH, Lee MJ et al. Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications. J Thromb Haemost 2005; 3: 497-501.
Hojo S, Tsukimori K, Kinukawa N et al. Decreased maternal protein S activity is associated with fetal growth restriction. Thromb Res 2008; 123: 55-59.
Ebina Y, Ieko M, Naito S et al. Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome. Thromb Haemost 2015; 114: 65-69.
Sorice M, Griggi T, Arcieri P et al. Protein S and HIV infection. The role of anticardiolipin and anti-protein S antibodies. Thromb Res 1994; 73: 165-175.
D'Angelo A, Della Valle P, Crippa L, Pattarini E, Grimaldi LM, Vigano D'Angelo S. Brief report: Autoimmune protein S deficiency in a boy with severe thromboembolic disease. N Engl J Med 1993; 328: 1753-1757.
Sato Y, Sugi T, Sakai R. Antigenic binding sites of anti-protein S autoantibodies in patients with recurrent pregnancy loss. Res Pract Thromb Haemost 2018; 2: 357-365.
Garrido-Gimenez C, Alijotas-Reig J. Recurrent miscarriage: Causes, evaluation and management. Postgrad Med J 2015; 91: 151-162.
Tanimura K, Jin H, Suenaga T et al. beta2-glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood 2015; 125: 2835-2844.
Kataoka K, Tomiya Y, Sakamoto A, Kamada Y, Hiramatsu Y, Nakatsuka M. Altered autonomic nervous system activity in women with unexplained recurrent pregnancy loss. J Obstet Gynaecol Res 2015; 41: 912-918.
Geller PA, Klier CM, Neugebauer R. Anxiety disorders following miscarriage. J Clin Psychiatry 2001; 62: 432-438.
Kagami M, Maruyama T, Koizumi T et al. Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss. Hum Reprod 2012; 27: 787-794.
Zhang YX, Zhang XQ, Wang QR et al. Psychological burden, sexual satisfaction and erectile function in men whose partners experience recurrent pregnancy loss in China: A cross-sectional study. Reprod Health 2016; 13: 73.
Lachmi-Epstein A, Mazor M, Bashiri A. Psychological and mental aspects and "tender loving care" among women with recurrent pregnancy losses. Harefuah 2012; 151: 633-637.