Elderberry (
adipokines
digestive enzymes
elderberry polyphenols
fat cells
functional food
glucose uptake
immune-metabolic effects
intracellular reactive oxygen species
obesity
Journal
Foods (Basel, Switzerland)
ISSN: 2304-8158
Titre abrégé: Foods
Pays: Switzerland
ID NLM: 101670569
Informations de publication
Date de publication:
08 Aug 2019
08 Aug 2019
Historique:
received:
11
07
2019
revised:
03
08
2019
accepted:
04
08
2019
entrez:
11
8
2019
pubmed:
11
8
2019
medline:
11
8
2019
Statut:
epublish
Résumé
Oxidative stress and inflammation in hypertrophied adipose tissue with excessive fat accumulation play a crucial role in the development of obesity and accompanying metabolic dysfunctions. This study demonstrated the capacity of elderberry fruit (EDB) extract to decrease the elevated production of reactive oxygen species in hypertrophied 3T3-L1 adipocytes. Treatment with the EDB extract resulted in modulation of mRNA expression and protein secretion of key adipokines in hypertrophied adipocytes. Expression of leptin and adiponectin was, respectively, down- and up-regulated. Moreover, glucose uptake stimulation was noticed in mature adipocytes, both sensitive to insulin and insulin resistant. This may suggest a positive effect of EDB extract on insulin resistance status. The extract was also found to alleviate the inflammatory response in activated RAW 264.7 macrophages by down-regulating the expression of proinflammatory genes (
Identifiants
pubmed: 31398785
pii: foods8080326
doi: 10.3390/foods8080326
pmc: PMC6724042
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NATIONAL SCIENCE CENTRE, POLAND
ID : 2015/19/B/NZ9/01054
Références
Obesity (Silver Spring). 2009 Jun;17(6):1150-7
pubmed: 19247274
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
J Clin Invest. 2000 Aug;106(4):473-81
pubmed: 10953022
Diabetes Metab Syndr Obes. 2010 Jul 16;3:253-62
pubmed: 21437093
Metab Syndr Relat Disord. 2015 Dec;13(10):423-44
pubmed: 26569333
Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2062-8
pubmed: 16123319
Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):446-452
pubmed: 27583706
Br J Nutr. 2015 Oct 28;114(8):1123-31
pubmed: 26314315
Biochem Pharmacol. 2003 Nov 1;66(9):1821-32
pubmed: 14563492
Vasc Health Risk Manag. 2006;2(2):163-9
pubmed: 17319461
Eur J Med Res. 2010 Nov 4;15 Suppl 2:120-2
pubmed: 21147638
J Agric Food Chem. 2017 Apr 5;65(13):2677-2685
pubmed: 28303711
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
Int J Mol Sci. 2016 Dec 22;18(1):
pubmed: 28025494
J Food Sci. 2012 Oct;77(10):C1064-70
pubmed: 22924969
Food Funct. 2015 Apr;6(4):1278-87
pubmed: 25758596
Gerontology. 2009;55(4):379-86
pubmed: 19365105
J Agric Food Chem. 2014 Jun 18;62(24):5573-80
pubmed: 24830391
Clin Chem. 2004 Sep;50(9):1511-25
pubmed: 15265818
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
Obes Res Clin Pract. 2013 Sep-Oct;7(5):e330-41
pubmed: 24455761
Expert Rev Clin Pharmacol. 2018 Jun;11(6):545-547
pubmed: 29667442
J Immunoassay Immunochem. 2006;27(1):31-44
pubmed: 16450867
Food Chem. 2016 Apr 15;197(Pt A):648-57
pubmed: 26616999
Expert Rev Clin Pharmacol. 2019 Jan;12(1):1-7
pubmed: 30484336
Int J Mol Sci. 2017 Mar 08;18(3):
pubmed: 28282861
J Ethnopharmacol. 2008 Jul 23;118(2):252-6
pubmed: 18487028
Pharm Biol. 2015 Apr;53(4):533-9
pubmed: 25327310
Front Endocrinol (Lausanne). 2013 Aug 08;4:93
pubmed: 23964268
Int J Endocrinol. 2013;2013:678159
pubmed: 23690772
Nature. 2000 Aug 17;406(6797):782-7
pubmed: 10963608
Prev Nutr Food Sci. 2017 Dec;22(4):251-262
pubmed: 29333376
PLoS One. 2017 Nov 28;12(11):e0188583
pubmed: 29182628
Food Chem. 2017 Jan 1;214:259-268
pubmed: 27507474
PLoS Comput Biol. 2009 Mar;5(3):e1000324
pubmed: 19325873
PLoS One. 2016 Apr 28;11(4):e0153751
pubmed: 27124181
J Agric Food Chem. 2014 May 21;62(20):4610-7
pubmed: 24785184
Expert Rev Cardiovasc Ther. 2008 Mar;6(3):343-68
pubmed: 18327995
Life Sci. 2015 May 1;128:30-8
pubmed: 25744406
J Funct Foods. 2018 Jan;40:377-390
pubmed: 32362939
Molecules. 2017 Oct 24;22(10):
pubmed: 29064442