Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers: Behavioral, Neural and Polygenic Correlates.
Pavlovian-to-instrumental transfer
alcohol
amygdala
high risk drinkers
polygenic risk
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 Aug 2019
08 Aug 2019
Historique:
received:
29
06
2019
revised:
04
08
2019
accepted:
06
08
2019
entrez:
11
8
2019
pubmed:
11
8
2019
medline:
11
8
2019
Statut:
epublish
Résumé
In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (
Identifiants
pubmed: 31398853
pii: jcm8081188
doi: 10.3390/jcm8081188
pmc: PMC6723486
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG FOR 1617
Références
Nature. 1999 Apr 15;398(6728):567-70
pubmed: 10217139
Synapse. 2003 Sep 15;49(4):226-31
pubmed: 12827641
J Neurosci. 2005 Jan 26;25(4):962-70
pubmed: 15673677
Recent Dev Alcohol. 2005;17:29-47
pubmed: 15789858
Nat Neurosci. 2005 Nov;8(11):1481-9
pubmed: 16251991
Pharmacol Biochem Behav. 2007 Feb;86(2):263-83
pubmed: 17116324
Curr Opin Pharmacol. 2007 Feb;7(1):69-76
pubmed: 17174602
Alcohol Clin Exp Res. 2007 May;31(5):766-74
pubmed: 17378919
J Neurosci. 2008 Jan 9;28(2):360-8
pubmed: 18184778
Science. 2008 Jun 6;320(5881):1352-5
pubmed: 18535246
Drug Alcohol Depend. 2009 May 1;101(3):169-75
pubmed: 19233572
Br J Addict. 1991 Sep;86(9):1119-27
pubmed: 1932883
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Nature. 2009 Oct 8;461(7265):747-53
pubmed: 19812666
Psychol Sci. 2011 Apr;22(4):490-7
pubmed: 21389338
Neuron. 2011 Mar 24;69(6):1204-15
pubmed: 21435563
PLoS Comput Biol. 2011 Apr;7(4):e1002028
pubmed: 21556131
Nat Rev Neurosci. 2011 Jun 02;12(7):400-13
pubmed: 21633380
Trends Cogn Sci. 2012 Jan;16(1):81-91
pubmed: 22155014
J Neurosci. 2012 Jun 13;32(24):8383-90
pubmed: 22699918
Nat Neurosci. 2012 Oct;15(10):1356-8
pubmed: 22922785
Addict Sci Clin Pract. 2012 Dec 07;7:25
pubmed: 23217219
Biol Psychiatry. 2013 Apr 15;73(8):747-55
pubmed: 23374641
PLoS One. 2013 Apr 30;8(4):e61355
pubmed: 23646106
J Cogn Neurosci. 2013 Sep;25(9):1428-41
pubmed: 23691985
Int J Methods Psychiatr Res. 2013 Jun;22(2):83-99
pubmed: 23788523
Neuropsychopharmacology. 2014 Feb;39(3):688-97
pubmed: 24060832
Neuron. 2014 Jan 8;81(1):207-17
pubmed: 24333054
Behav Neurosci. 2014 Feb;128(1):71-82
pubmed: 24512067
PLoS One. 2014 Apr 14;9(4):e94605
pubmed: 24732090
Front Behav Neurosci. 2014 May 07;8:161
pubmed: 24847229
Behav Res Ther. 2014 Aug;59:61-70
pubmed: 25011113
Front Behav Neurosci. 2014 Sep 18;8:329
pubmed: 25278858
Neuropsychobiology. 2014;70(2):111-21
pubmed: 25359491
Eur J Neurosci. 2015 Feb;41(4):477-86
pubmed: 25546072
Addict Biol. 2016 May;21(3):719-31
pubmed: 25828702
Annu Rev Psychol. 2016;67:23-50
pubmed: 26253543
Neurosci Biobehav Rev. 2015 Oct;57:271-83
pubmed: 26341938
Drug Alcohol Depend. 2015 Nov 1;156:1-13
pubmed: 26371405
Transl Psychiatry. 2016 Mar 22;6:e761
pubmed: 27003187
PLoS One. 2016 Nov 30;11(11):e0167360
pubmed: 27902751
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377
pubmed: 27911795
Alcohol Clin Exp Res. 2017 Jan;41(1):65-75
pubmed: 27991676
Addict Biol. 2018 Jan;23(1):379-393
pubmed: 28111829
Psychopharmacology (Berl). 2017 Jul;234(13):1977-1984
pubmed: 28412771
Eur J Neurosci. 2017 Jul;46(2):1815-1827
pubmed: 28444823
Biol Psychiatry. 2017 Dec 1;82(11):847-856
pubmed: 28673442
Transl Psychiatry. 2017 Aug 1;7(8):e1183
pubmed: 28763064
Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91
pubmed: 8401595
Alcohol Clin Exp Res. 1996 Dec;20(9):1594-8
pubmed: 8986209
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
Addict Behav. 1997 Jul-Aug;22(4):557-65
pubmed: 9290864