Growing a new human kidney.
disease
gene
mesonephros
metanephros
organoid
regeneration
stem cell
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
01
2019
revised:
01
03
2019
accepted:
01
04
2019
pubmed:
11
8
2019
medline:
21
10
2020
entrez:
11
8
2019
Statut:
ppublish
Résumé
There are 3 reasons to generate a new human kidney. The first is to learn more about the biology of the developing and mature organ. The second is to generate tissues with which to model congenital and acquired kidney diseases. In particular, growing human kidneys in this manner ultimately should help us understand the mechanisms of common chronic kidney diseases such as diabetic nephropathy and others featuring fibrosis, as well as nephrotoxicity. The third reason is to provide functional kidney tissues that can be used directly in regenerative medicine therapies. The second and third reasons to grow new human kidneys are especially compelling given the millions of persons worldwide whose lives depend on a functioning kidney transplant or long-term dialysis, as well as those with end-stage renal disease who die prematurely because they are unable to access these treatments. As shown in this review, the aim to create healthy human kidney tissues has been partially realized. Moreover, the technology shows promise in terms of modeling genetic disease. In contrast, barely the first steps have been taken toward modeling nongenetic chronic kidney diseases or using newly grown human kidney tissue for regenerative medicine therapies.
Identifiants
pubmed: 31399199
pii: S0085-2538(19)30529-0
doi: 10.1016/j.kint.2019.04.040
pmc: PMC6856720
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
871-882Subventions
Organisme : Medical Research Council
ID : MR/K026739/1
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
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