Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study.

Aged Alzheimer Disease / diagnostic imaging Amyloid beta-Peptides / metabolism Biomarkers Brain / pathology Cross-Sectional Studies Disease Progression Female Humans Longitudinal Studies Male Positron-Emission Tomography Prodromal Symptoms Prognosis tau Proteins / metabolism
Alzheimer's disease Biomarker Prognosis Research framework

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
09 2019
Historique:
received: 12 02 2019
revised: 21 05 2019
accepted: 21 05 2019
pubmed: 11 8 2019
medline: 8 8 2020
entrez: 11 8 2019
Statut: ppublish

Résumé

We aimed to estimate the frequency of each AT(N) (β-amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group. Longitudinal change in clinical outcomes and conversion risk of AT(N) profiles are assessed using linear mixed-effects models and multivariate Cox proportional-hazard models, respectively. Participants with A+T+N+ showed faster clinical progression than those with A-T-N- and A+T±N-. Compared with A-T-N-, participants with A+T+N± had an increased risk of conversion from cognitively normal (CN) to incident prodromal stage of Alzheimer's disease (AD), and from MCI to AD dementia. A+T+N+ showed an increased conversion risk when compared with A+T±N-. The 2018 research framework may provide prognostic information of clinical change and progression. It may also be useful for targeted recruitment of participants with AD into clinical trials.

Identifiants

DOI: 10.1016/j.jalz.2019.05.006 PMID: 31399333
pubmed: 31399333
pii: S1552-5260(19)30147-5
doi: 10.1016/j.jalz.2019.05.006
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1208-1217

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Auteurs

Jin-Tai Yu (JT)

Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: jintai_yu@fudan.edu.cn.

Jie-Qiong Li (JQ)

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

John Suckling (J)

Department of Psychiatry, University of Cambridge, Cambridge, UK; Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Trust, Cambridge, UK.

Lei Feng (L)

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

An Pan (A)

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yan-Jiang Wang (YJ)

Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.

Bo Song (B)

College of Information Science and Technology, Qingdao University of Science and Technology, Qingdao, China.

Shan-Liang Zhu (SL)

Research Center for Mathematical Modeling, School of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao, China.

De-Hu Li (DH)

Research Center for Mathematical Modeling, School of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao, China.

Hui-Fu Wang (HF)

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Chen-Chen Tan (CC)

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Qiang Dong (Q)

Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Lan Tan (L)

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Vincent Mok (V)

Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Therese Pei Fong Chow Research Center for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Paul S Aisen (PS)

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA.

Michael M Weiner (MM)

Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Diagnostic › Symptômes prodromiques › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Diagnostic › Pronostic › Frequency and longitudinal clinical outcomes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Frequency and longitudinal clinical outcomes...