Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition.
Animals
Bacteria
/ classification
Biodiversity
Diabetes Mellitus, Type 2
/ complications
Diet
Dietary Supplements
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Germany
Humans
Iron
/ metabolism
Magnesium
/ metabolism
Male
Metabolic Diseases
/ complications
Metagenomics
Mice
Mice, Inbred C57BL
Multivariate Analysis
Nutrition Assessment
Obesity
/ complications
Serum
/ metabolism
dietary supplements
iron
magnesium
medication
metabolic disease
microbiome
nutrition
obesity
type 2 diabetes
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
14 08 2019
14 08 2019
Historique:
received:
14
01
2019
revised:
17
05
2019
accepted:
16
07
2019
pubmed:
11
8
2019
medline:
20
12
2019
entrez:
11
8
2019
Statut:
ppublish
Résumé
Obesity and type 2 diabetes (T2D) are metabolic disorders that are linked to microbiome alterations. However, their co-occurrence poses challenges in disentangling microbial features unique to each condition. We analyzed gut microbiomes of lean non-diabetic (n = 633), obese non-diabetic (n = 494), and obese individuals with T2D (n = 153) from German population and metabolic disease cohorts. Microbial taxonomic and functional profiles were analyzed along with medical histories, serum metabolomics, biometrics, and dietary data. Obesity was associated with alterations in microbiome composition, individual taxa, and functions with notable changes in Akkermansia, Faecalibacterium, Oscillibacter, and Alistipes, as well as in serum metabolites that correlated with gut microbial patterns. However, microbiome associations were modest for T2D, with nominal increases in Escherichia/Shigella. Medications, including antihypertensives and antidiabetics, along with dietary supplements including iron, were significantly associated with microbiome variation. These results differentiate microbial components of these interrelated metabolic diseases and identify dietary and medication exposures to consider in future studies.
Identifiants
pubmed: 31399369
pii: S1931-3128(19)30348-8
doi: 10.1016/j.chom.2019.07.004
pmc: PMC7720933
mid: NIHMS1648697
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Magnesium
I38ZP9992A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-264.e10Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144651
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL028481
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL069766
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK110499
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM083198
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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