Cocaine potently blocks neuronal α


Journal

Acta pharmacologica Sinica
ISSN: 1745-7254
Titre abrégé: Acta Pharmacol Sin
Pays: United States
ID NLM: 100956087

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 06 01 2019
accepted: 23 06 2019
pubmed: 11 8 2019
medline: 24 10 2020
entrez: 11 8 2019
Statut: ppublish

Résumé

Cocaine is one of the most abused illicit drugs worldwide. It is well known that the dopamine (DA) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nAChRs). In this study, we investigated the effects of cocaine on a special subtype of neuronal nAChR, α

Identifiants

pubmed: 31399700
doi: 10.1038/s41401-019-0276-y
pii: 10.1038/s41401-019-0276-y
pmc: PMC7471406
doi:

Substances chimiques

Receptors, Nicotinic 0
nicotinic receptor alpha3beta4 0
nicotinic receptor alpha4beta2 0
Nicotine 6M3C89ZY6R
Cocaine I5Y540LHVR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-172

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA011064
Pays : United States

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Auteurs

Ze-Gang Ma (ZG)

Department of Physiology, Institute of Brain Science and Disorders, Medical College of Qingdao University, Qingdao, 266071, China.
Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Nan Jiang (N)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.
Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

Yuan-Bing Huang (YB)

Department of Neurology, Yunfu People's Hospital, Yunfu, 527300, China.

Xiao-Kuang Ma (XK)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.
Department of Physiology, Shantou University Medical College, Shantou, 515004, China.

Jason Brek Eaton (J)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Ming Gao (M)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Yong-Chang Chang (YC)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Ronald J Lukas (RJ)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Paul Whiteaker (P)

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.

Janet Neisewander (J)

School of Life Sciences, Arizona State University, Tempe, AZ, 85287-4501, USA.

Jie Wu (J)

Department of Physiology, Institute of Brain Science and Disorders, Medical College of Qingdao University, Qingdao, 266071, China. jie.wu@DignityHealth.org.
Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA. jie.wu@DignityHealth.org.
Department of Neurology, Yunfu People's Hospital, Yunfu, 527300, China. jie.wu@DignityHealth.org.
Department of Physiology, Shantou University Medical College, Shantou, 515004, China. jie.wu@DignityHealth.org.

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