The role of chemokines and chemokine receptors in pulmonary arterial hypertension.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
17
05
2019
revised:
25
07
2019
accepted:
26
07
2019
pubmed:
11
8
2019
medline:
22
6
2021
entrez:
11
8
2019
Statut:
ppublish
Résumé
Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload, which results in right heart failure and premature death. Inflammation plays a central role in the development of PAH, and the recruitment and function of immune cells are tightly regulated by chemotactic cytokines called chemokines. A number of studies have shown that the development and progression of PAH are associated with the dysregulated expression of several chemokines and chemokine receptors in the pulmonary vasculature. Moreover, some chemokines are differentially regulated in the pressure-overloaded right ventricle. Recent studies have tested the efficacy of pharmacological agents targeting several chemokines and chemokine receptors for their effects on the development of PAH, suggesting that these receptors could serve as useful therapeutic targets. In this review, we provide recent insights into the role of chemokines and chemokine receptors in PAH and RV remodelling and the opportunities and roadblocks in targeting them. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc.
Substances chimiques
Chemokines
0
Receptors, Chemokine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-89Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1213
Organisme : American Heart Association
ID : 33670458
Organisme : British Heart Foundation
ID : FS/18/52/33808
Pays : United Kingdom
Informations de copyright
© 2019 The British Pharmacological Society.
Références
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