p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor.
CDKI
CIP/KIP
INK4
biological function
expression regulation
p19INK4d.
Journal
Current drug targets
ISSN: 1873-5592
Titre abrégé: Curr Drug Targets
Pays: United Arab Emirates
ID NLM: 100960531
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
05
2019
revised:
11
07
2019
accepted:
17
07
2019
pubmed:
11
8
2019
medline:
3
2
2021
entrez:
11
8
2019
Statut:
ppublish
Résumé
Cyclin-dependent kinase inhibitors (CDKIs) are important cell cycle regulators. The CDKI family is composed of the INK4 family and the CIP/KIP family. p19INK4d belongs to the INK4 gene family and is involved in a series of normal physiological activities and the pathogenesis of diseases. Many factors play regulatory roles in the p19INK4d gene expression at the transcriptional and posttranscriptional levels. p19INK4d not only regulates the cell cycle but also plays regulatory roles in apoptosis, DNA damage repair, cell differentiation of hematopoietic cells, and cellular senescence. In this review, the regulatory network of the p19INK4d gene expression and its biological functions are summarized, which provides a basis for further study of p19INK4d as a drug target for disease treatment.
Identifiants
pubmed: 31400265
pii: CDT-EPUB-100266
doi: 10.2174/1389450120666190809161901
doi:
Substances chimiques
Cdkn2d protein, mouse
0
Cyclin-Dependent Kinase Inhibitor p19
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-102Informations de copyright
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