Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

Adult Cognition Conflict, Psychological Depressive Disorder, Major / diagnostic imaging Emotions / physiology Facial Recognition Female Humans Magnetic Resonance Imaging / methods Male Occipital Lobe / diagnostic imaging Reaction Time Stroop Test Task Performance and Analysis

Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
01 10 2019
Historique:
received: 13 04 2019
revised: 12 06 2019
accepted: 04 07 2019
pubmed: 11 8 2019
medline: 26 6 2020
entrez: 11 8 2019
Statut: ppublish

Résumé

We studied 48 MDD and 30 HC who performed an emotional conflict task in a functional magnetic resonance imaging (fMRI) scanner. On the emotional conflict task, MDD and HC demonstrated a robust emotional Stroop effect in reaction time and accuracy. Overall, accuracy was lower in MDD compared to HC with no significant reaction time differences. The fMRI data indicated lower BOLD activation in MDD compared to HC on comparisons of all trials, congruent, incongruent, and incongruent > congruent trials in regions including right inferior temporal gyrus, lateral occipital cortex, and occipital fusiform gyrus. Behavioural and neuroimaging data indicated no group differences in fearful versus happy face processing. Inclusion of a neutral condition may have provided a valuable contrast to how MDD and HC process stimuli without emotional valence compared to stimuli with a strong emotional valence. MDD and HC demonstrated a robust emotional Stroop effect. Compared to HC, MDD demonstrated an overall reduced accuracy on the emotional conflict task and reduced BOLD activity in regions important for face perception and emotion information processing, with no differences in responding to fearful versus happy faces. These findings provide support for the theory of emotion context insensitivity in individuals with depression.

Identifiants

DOI: 10.1016/j.jad.2019.07.037 PMID: 31400735
pubmed: 31400735
pii: S0165-0327(19)30969-3
doi: 10.1016/j.jad.2019.07.037
pii:
doi:

Types de publication

Clinical Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

765-773

Subventions

Organisme : CIHR
ID : MOP137097
Pays : Canada

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Gésine L Alders (GL)

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.

Andrew D Davis (AD)

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Glenda MacQueen (G)

Mathison Centre for Mental Health Research and Education, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Stephen C Strother (SC)

Rotman Research Institute, Baycrest, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, ON, Canada.

Stefanie Hassel (S)

Mathison Centre for Mental Health Research and Education, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Mojdeh Zamyadi (M)

Rotman Research Institute, Baycrest, Toronto, ON, Canada.

Gulshan B Sharma (GB)

Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Stephen R Arnott (SR)

Rotman Research Institute, Baycrest, Toronto, ON, Canada.

Jonathan Downar (J)

Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.

Jacqueline K Harris (JK)

Department of Computer Science, University of Alberta, Edmonton, AB, Canada.

Raymond W Lam (RW)

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Roumen Milev (R)

Departments of Psychiatry and Psychology, Queen's University, Providence Care Hospital, Kingston, ON, Canada.

Daniel J Müller (DJ)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, Canada.

Arun Ravindran (A)

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Sidney H Kennedy (SH)

Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Centre for Depression and Suicide Studies, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Benicio N Frey (BN)

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.

Luciano Minuzzi (L)

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, ON, Canada.

Geoffrey B Hall (GB)

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address: hall@mcmaster.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Conflit (psychologie) › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception visuelle › Reconnaissance visuelle des formes › Reconnaissance faciale › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe occipital › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Temps de réaction › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Test de Stroop › Reduced accuracy accompanied by reduced neural...
questionsmedicales.fr › Phénomènes psychologiques › Analyse et exécution des tâches › Reduced accuracy accompanied by reduced neural...