Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.

APOBEC-3G Deaminase / genetics Aminohydrolases / genetics Antiviral Agents / metabolism Cell Line, Tumor Cytidine Deaminase / genetics DNA, Viral / genetics Gene Expression Regulation Genetic Variation Hepatitis B virus / physiology Humans Somatic Hypermutation, Immunoglobulin / genetics Virus Replication
APOBEC Antiviral protein Cytidine deaminase Hepatitis B virus

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
08 10 2019
Historique:
received: 11 07 2019
accepted: 01 08 2019
pubmed: 12 8 2019
medline: 2 6 2020
entrez: 12 8 2019
Statut: ppublish

Résumé

Some APOBEC3 family members have antiviral activity against retroviruses and DNA viruses. Hepatitis B virus (HBV) is a DNA virus that is the major causative factor of severe liver diseases such as cirrhosis and hepatocellular carcinoma. To determine whether APOBEC3 variants in humans have different anti-HBV activities, we evaluated natural variants of APOBEC3C, APOBEC3G, and APOBEC3H using an HBV-replicating cell culture model. Our data demonstrate that the APOBEC3C variant S188I had increased restriction activity and hypermutation frequency against HBV DNA. In contrast, the APOBEC3G variant H186R did not alter the anti-HBV and hypermutation activities. Among APOBEC3H polymorphisms (hap I-VII) and splicing variants (SV-200, SV-183, SV-182, and SV-154), hap II SV-183 showed the strongest restriction activity. These data suggest that the genetic variations in APOBEC3 genes may affect the efficiency of HBV elimination in humans.

Identifiants

DOI: 10.1016/j.bbrc.2019.08.003 PMID: 31400856
pubmed: 31400856
pii: S0006-291X(19)31505-0
doi: 10.1016/j.bbrc.2019.08.003
pii:
doi:

Substances chimiques

Antiviral Agents 0
DNA, Viral 0
APOBEC3H protein, human EC 3.5.4.-
Aminohydrolases EC 3.5.4.-
APOBEC-3G Deaminase EC 3.5.4.5
APOBEC3C protein, human EC 3.5.4.5
APOBEC3G protein, human EC 3.5.4.5
Cytidine Deaminase EC 3.5.4.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-31

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Arun Kanagaraj (A)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Naoya Sakamoto (N)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Lusheng Que (L)

Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.

Yingfang Li (Y)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.

Md Mohiuddin (M)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Miki Koura (M)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Kousho Wakae (K)

Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.

Makoto Kurachi (M)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Masamichi Muramatsu (M)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. Electronic address: muramatsu@nih.go.jp.

Kouichi Kitamura (K)

Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. Electronic address: kkita@med.kanazawa-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de restriction antiviraux › APOBEC-3G Deaminase › Different antiviral activities of natural...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Different antiviral activities of natural...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Different antiviral activities of natural...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Different antiviral activities of natural...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Nucleoside deaminases › Cytidine deaminase › Different antiviral activities of natural...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › Different antiviral activities of natural...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Different antiviral activities of natural...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Different antiviral activities of natural...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Different antiviral activities of natural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Different antiviral activities of natural...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Hypermutation somatique des gènes des immunoglobulines › Different antiviral activities of natural...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Different antiviral activities of natural...