Development of

Humans Radioisotopes / chemistry Receptors, Nicotinic / metabolism Technetium / chemistry Tomography, Emission-Computed, Single-Photon / methods
A85380 derivatives Docking simulation Nicotinic acetylcholine receptors Single-photon emission computed tomography Technetium-99m

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 09 2019
Historique:
received: 15 03 2019
revised: 25 07 2019
accepted: 30 07 2019
pubmed: 12 8 2019
medline: 18 9 2020
entrez: 12 8 2019
Statut: ppublish

Résumé

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that have been implicated in higher brain functions. To elucidate the functional mechanisms underlying nAChRs and contribute significantly to development of drugs targeting neurological and neuropsychiatric diseases, non-invasive nuclear medical imaging can be used for evaluation. In addition, technetium-99m (

Identifiants

DOI: 10.1016/j.bmc.2019.07.053 PMID: 31401009
pubmed: 31401009
pii: S0968-0896(19)30418-3
doi: 10.1016/j.bmc.2019.07.053
pii:
doi:

Substances chimiques

Radioisotopes 0
Receptors, Nicotinic 0
Technetium 7440-26-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4200-4210

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Daisuke Mori (D)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

Hiroyuki Kimura (H)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan. Electronic address: hkimura@mb.kyoto-phu.ac.jp.

Hidekazu Kawashima (H)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Radioisotope Research Center, Kyoto Pharmaceutical University, Kyoto, Japan.

Yusuke Yagi (Y)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan.

Kenji Arimitsu (K)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan.

Masahiro Ono (M)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

Hideo Saji (H)

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. Electronic address: hsaji@pharm.kyoto-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Development of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Development of
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Technétium › Development of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Development of