Long term renal function in Asian HIV-1 infected adults receiving tenofovir disoproxil fumarate without protease inhibitors.
Body weight
HIV
Kidney
Protease inhibitors (PI)
Tenofovir disoproxil fumarate (TDF)
Thailand
eGFR
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
02
2019
revised:
19
07
2019
accepted:
06
08
2019
pubmed:
12
8
2019
medline:
17
7
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
The risk of kidney dysfunction on the WHO recommended first line regimens containing tenofovir disoproxil fumarate (TDF) without protease inhibitors (PI) remains unclear in Asian patients, especially those with low body weight. Using data collected in a multicenter clinical trial in Thailand and proportional hazard regression models, we compared the risk of a >25% estimated glomerular filtration rate (eGFR) reduction in HIV naïve patients initiating TDF or zidovudine (AZT) containing non-PI regimen. Of 640 patients included in the analysis, 461 (72%) received a TDF-containing regimen for a median 6.7 years and 179 (28%) an AZT-containing regimen for 6.5 years. The risk of a >25% eGFR reduction was not associated with treatment (HR 1.11, 95% CI 0.84-1.47, P = 0.46). In multivariate analysis, the risk of >25% eGFR reduction form baseline was associated with body weight at baseline (HR 2.12, 95% CI 1.48-3.02 for <48 kg patients and HR 1.64, 95% CI 1.20-2.25 for 48-59.9 kg patients, compared to those with >60 kg, P < 0.001) and hypertension (HR 4.03, 95% CI 2.0-8.0, P < 0.001). The effect of baseline weight on >25% eGFR reduction did not significantly vary with treatment (P = 0.27). The risk of eGFR reduction was not higher on TDF- versus AZT-based non-PI regimens. Although the risk of eGFR reduction was greater for patients of lower body weight, this risk was not significantly increased by TDF.
Identifiants
pubmed: 31401085
pii: S0163-4453(19)30245-2
doi: 10.1016/j.jinf.2019.08.006
pmc: PMC6825894
mid: NIHMS1538874
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Zidovudine
4B9XT59T7S
Tenofovir
99YXE507IL
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
454-461Subventions
Organisme : NICHD NIH HHS
ID : R01 HD042964
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
Références
Antivir Ther. 2011;16(1):119-21
pubmed: 21311116
Clin Infect Dis. 2005 Jun 1;40(11):1559-85
pubmed: 15889353
Antimicrob Agents Chemother. 2009 May;53(5):1937-43
pubmed: 19273671
J Infect Dis. 2013 May 1;207(9):1359-69
pubmed: 23382571
Clin Chem. 2007 Apr;53(4):766-72
pubmed: 17332152
Int J Clin Pharm. 2015 Oct;37(5):865-72
pubmed: 26008219
Clin Infect Dis. 2014 Nov 1;59(9):e96-138
pubmed: 25234519
Antivir Ther. 2007;12(2):267-72
pubmed: 17503669
Nephrol Dial Transplant. 2011 Sep;26(9):2780-5
pubmed: 21357214
PLoS One. 2012;7(1):e29977
pubmed: 22242194
AIDS. 2012 Sep 10;26(14):1781-8
pubmed: 22713478
J Infect Chemother. 2014 Dec;20(12):784-8
pubmed: 25301140
PLoS Med. 2013 Aug;10(8):e1001494
pubmed: 23940461
Ann Intern Med. 1999 Mar 16;130(6):461-70
pubmed: 10075613
AIDS Patient Care STDS. 2017 Mar;31(3):105-112
pubmed: 28282247
Clin Infect Dis. 2003 Dec 15;37(12):e174-6
pubmed: 14689363
J Virus Erad. 2016 Nov 28;2(Suppl 4):1-6
pubmed: 28303199
PLoS One. 2011;6(7):e22661
pubmed: 21799928
Indian J Sex Transm Dis AIDS. 2010 Jan;31(1):30-4
pubmed: 21808434
Ther Drug Monit. 1983 Jun;5(2):161-8
pubmed: 6879639
AIDS. 2009 Mar 27;23(6):689-96
pubmed: 19262355
J Infect Dis. 2008 Jan 1;197(1):102-8
pubmed: 18171292
Clin Pharmacol Ther. 2008 Feb;83(2):265-72
pubmed: 17597712
AIDS. 2014 Aug 24;28(13):1903-10
pubmed: 25259702
Adv Chronic Kidney Dis. 2013 Sep;20(5):390-5
pubmed: 23978543
AIDS. 2018 Jan 28;32(3):393-398
pubmed: 29135575
BMC Infect Dis. 2013 Jul 01;13:301
pubmed: 23815472
Antivir Ther. 2006;11(1):79-86
pubmed: 16518963
Nephrol Dial Transplant. 2012 Oct;27(10):3835-43
pubmed: 22764191
AIDS. 2010 Jul 17;24(11):1667-78
pubmed: 20523203
Am J Kidney Dis. 2007 Jul;50(1):21-35
pubmed: 17591522
PLoS One. 2013 Dec 02;8(12):e80242
pubmed: 24312465
J Int AIDS Soc. 2016 Feb 02;19(1):20504
pubmed: 26842728
Clin Infect Dis. 2010 Sep 1;51(5):496-505
pubmed: 20673002
Lancet HIV. 2016 Jan;3(1):e23-32
pubmed: 26762990
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
Clin Infect Dis. 2003 Apr 15;36(8):1070-3
pubmed: 12684922
Curr HIV Res. 2010 Oct;8(7):504-9
pubmed: 21073439
Kidney Int. 2008 Aug;74(4):415-7
pubmed: 18670407
AIDS. 2015 Feb 20;29(4):503-4
pubmed: 25628258