Multifaceted ABC transporters associated to microcin and bacteriocin export.
ABC exporter
AMS/PCAT exporter
ATP-binding cassette
Antimicrobial peptides
Bacteriocins
Microcins
Journal
Research in microbiology
ISSN: 1769-7123
Titre abrégé: Res Microbiol
Pays: France
ID NLM: 8907468
Informations de publication
Date de publication:
Historique:
received:
29
03
2019
revised:
12
07
2019
accepted:
17
07
2019
pubmed:
12
8
2019
medline:
10
1
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
Microcins and bacteriocins are ribosomally-synthesized defence peptides produced by Gram-negative and -positive bacteria to target competitors in their niche. Some of them carry posttranslational modifications established by dedicated enzymes. To protect themselves from their own toxic peptides, bacteria use dedicated immunity proteins or expel the toxin using ATP-binding cassette (ABC) transporters. In this last case, this immunity function is associated to export of the antimicrobial peptide out of the producing cells for targeting their competitors. Here we review the characteristics of these ABC-exporters and the mechanisms they use that unexpectedly cover from high promiscuity to high specificity or ensure another function concomitantly.
Identifiants
pubmed: 31401108
pii: S0923-2508(19)30081-6
doi: 10.1016/j.resmic.2019.07.002
pii:
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Anti-Bacterial Agents
0
Antimicrobial Cationic Peptides
0
Bacteriocins
0
microcin
1403-96-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
399-406Subventions
Organisme : Medical Research Council
ID : MR/N020103/1
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Masson SAS. All rights reserved.