A prospective study comparing tendon-to-bone interface healing using an interposition bioresorbable scaffold with a vented anchor for primary rotator cuff repair in sheep.
Absorbable Implants
Animals
Biocompatible Materials
/ therapeutic use
Biomechanical Phenomena
Bone and Bones
/ physiology
Cell Count
Collagen Type III
/ metabolism
Disease Models, Animal
Female
Fibroblasts
Osteogenesis
Polylactic Acid-Polyglycolic Acid Copolymer
/ therapeutic use
Prospective Studies
Rotator Cuff Injuries
/ pathology
Sheep
Suture Techniques
Tendons
/ physiology
Tissue Scaffolds
Wound Healing
PLGA scaffold
Rotator cuff repair
biomechanics
histology
ovine
rotator cuff tendon
suture anchor
Journal
Journal of shoulder and elbow surgery
ISSN: 1532-6500
Titre abrégé: J Shoulder Elbow Surg
Pays: United States
ID NLM: 9206499
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
02
01
2019
revised:
03
05
2019
accepted:
13
05
2019
pubmed:
12
8
2019
medline:
14
3
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(l-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model. Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were evaluated and compared. The Treatment group had a significantly higher fibroblast count at 7 weeks compared to the Control group. The tendon bone repair distance, percentage perpendicular fibers, new bone formation at the tendon-bone interface, and collagen type III deposition was significantly greater for the Treatment group compared with the Control group at 12 weeks (P ≤ .05). A positive correlation was identified in the Treatment group between increased failure loads at 12 weeks and the following parameters: tendon-bone integration, new bone formation, and collagen type III. No statistically significant differences in biomechanical properties were identified between Treatment and Control Groups (P > .05). Use of a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA microfibers improves the histologic properties of rotator cuff repairs in a sheep model. Improved histology was correlated with improved final construct strength at the 12-week time point.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(l-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model.
METHODS
METHODS
Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were evaluated and compared.
RESULTS
RESULTS
The Treatment group had a significantly higher fibroblast count at 7 weeks compared to the Control group. The tendon bone repair distance, percentage perpendicular fibers, new bone formation at the tendon-bone interface, and collagen type III deposition was significantly greater for the Treatment group compared with the Control group at 12 weeks (P ≤ .05). A positive correlation was identified in the Treatment group between increased failure loads at 12 weeks and the following parameters: tendon-bone integration, new bone formation, and collagen type III. No statistically significant differences in biomechanical properties were identified between Treatment and Control Groups (P > .05).
CONCLUSIONS
CONCLUSIONS
Use of a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA microfibers improves the histologic properties of rotator cuff repairs in a sheep model. Improved histology was correlated with improved final construct strength at the 12-week time point.
Identifiants
pubmed: 31401128
pii: S1058-2746(19)30359-3
doi: 10.1016/j.jse.2019.05.024
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Collagen Type III
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-166Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.