T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Adaptive Immunity
Adolescent
Allergens
/ immunology
Amish
Cells, Cultured
Child
Environmental Exposure
/ adverse effects
Ethnicity
Female
Humans
Hypersensitivity, Immediate
/ immunology
Immunoglobulin E
/ blood
Immunophenotyping
Male
Phenotype
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes
/ immunology
Tumor Necrosis Factor alpha-Induced Protein 3
/ genetics
Asthma
CD4 T cells
CD8 T cells
T-cell activation
adaptive immunity
atopy
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
24
01
2019
revised:
31
05
2019
accepted:
02
07
2019
pubmed:
12
8
2019
medline:
17
6
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
Amish children raised on traditional farms have lower atopy and asthma risk than Hutterite children raised on modern farms. In our previous study we established that the Amish environment affects the innate immune response to decrease asthma and atopy risk. Here we investigated T-cell phenotypes in the same Amish and Hutterite children as in our earlier study to elucidate how this altered innate immunity affects adaptive T cells. Blood was collected from 30 Amish and 30 Hutterite age- and sex-matched children; cells were cryopreserved until analysis. Flow cytometry was used to analyze cell subsets. Atopy was determined based on allergen-specific and total IgE levels. Children exposed to Amish farms had increased activated regulatory CD4 Amish children's blood leukocytes are not only altered in their innate immune status but also have distinct T-cell phenotypes that are often associated with increased antigen exposure.
Identifiants
pubmed: 31401285
pii: S0091-6749(19)31030-9
doi: 10.1016/j.jaci.2019.07.034
pmc: PMC6842432
mid: NIHMS1537151
pii:
doi:
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
TNFAIP3 protein, human
EC 3.4.19.12
Tumor Necrosis Factor alpha-Induced Protein 3
EC 3.4.19.12
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1391-1401.e10Subventions
Organisme : NIAID NIH HHS
ID : R01 AI125644
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007605
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014599
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085197
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI095230
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118758
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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