The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Na
Benzylamines
/ pharmacology
Calcium
/ metabolism
Calcium Signaling
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ antagonists & inhibitors
Calmodulin
/ chemistry
Cells, Cultured
Crystallography, X-Ray
Humans
Myocytes, Cardiac
NAV1.5 Voltage-Gated Sodium Channel
/ chemistry
Phosphorylation
Protein Binding
Protein Conformation
Ryanodine
/ metabolism
Ryanodine Receptor Calcium Release Channel
/ chemistry
Sulfonamides
/ pharmacology
CaMKII inhibition
Calcium calmodulin dependent kinase type II (CaMKII)
Calcium signaling
KN92
KN93
autocamtide-2-inhibitor peptide
Journal
Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
27
04
2019
revised:
15
07
2019
accepted:
26
07
2019
pubmed:
12
8
2019
medline:
10
9
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein kinase II (CaMKII) inhibitor KN93 bound to the Ca
Identifiants
pubmed: 31401388
pii: S0143-4160(19)30130-7
doi: 10.1016/j.ceca.2019.102063
pmc: PMC6708471
mid: NIHMS1536661
pii:
doi:
Substances chimiques
Benzylamines
0
CALM3 protein, human
0
Calmodulin
0
NAV1.5 Voltage-Gated Sodium Channel
0
Ryanodine Receptor Calcium Release Channel
0
SCN5A protein, human
0
Sulfonamides
0
KN 93
139298-40-1
Ryanodine
15662-33-6
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
102063Subventions
Organisme : NCRR NIH HHS
ID : S10 RR025677
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092097
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138579
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063043
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL127299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL144980
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139065
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL074045
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138539
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008320
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL117612
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130231
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118089
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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