Dehydration affects drug transport over nasal mucosa.
Mucoadhesion
dehydration
drug transport
nasal drug delivery
water activity
Journal
Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
13
8
2019
pubmed:
14
8
2019
medline:
1
2
2020
Statut:
ppublish
Résumé
Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and
Identifiants
pubmed: 31401887
doi: 10.1080/10717544.2019.1650848
pmc: PMC6713119
doi:
Substances chimiques
Excipients
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
831-840Références
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