MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.

Animals Cell Line Female HEK293 Cells Homeostasis / immunology Humans Immunity, Innate / immunology Killer Cells, Natural / immunology Lymphocytes / immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL MicroRNAs / immunology Muromegalovirus / immunology NIH 3T3 Cells Receptors, Interleukin-15 / immunology Signal Transduction / immunology Suppressor of Cytokine Signaling Proteins / immunology Transforming Growth Factor beta / immunology
IL-15 ILC1-like cells NK cells cytokine receptors innate lymphoid cells integrin microRNA-142 murine cytomegalovirus tissue resident

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 09 2019
Historique:
received: 21 02 2018
revised: 16 05 2019
accepted: 20 06 2019
pubmed: 14 8 2019
medline: 18 12 2019
entrez: 13 8 2019
Statut: ppublish

Résumé

Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms controlling their development and function remain incompletely understood. We hypothesized that the abundantly expressed microRNA-142 (miR-142) is a critical regulator of type 1 ILC biology. Interleukin-15 (IL-15) signaling induced miR-142 expression, whereas global and ILC-specific miR-142-deficient mice exhibited a cell-intrinsic loss of NK cells. Death of NK cells resulted from diminished IL-15 receptor signaling within miR-142-deficient mice, likely via reduced suppressor of cytokine signaling-1 (Socs1) regulation by miR-142-5p. ILCs persisting in Mir142

Identifiants

DOI: 10.1016/j.immuni.2019.06.016 PMID: 31402259 PMC: PMC6750984
pubmed: 31402259
pii: S1074-7613(19)30286-9
doi: 10.1016/j.immuni.2019.06.016
pmc: PMC6750984
mid: NIHMS1537077
pii:
doi:

Substances chimiques

MicroRNAs 0
Mirn142 microRNA, mouse 0
Receptors, Interleukin-15 0
Suppressor of Cytokine Signaling Proteins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

479-490.e6

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK103039
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA173878
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125615
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA171963
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205239
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007200
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127752
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA101937
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025884
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007088
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA143379
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090775
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA200253
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI078994
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA197369
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009547
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI102924
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI129110
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095542
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Melissa M Berrien-Elliott (MM)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Yaping Sun (Y)

Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.

Carly Neal (C)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Aaron Ireland (A)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Maria C Trissal (MC)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Ryan P Sullivan (RP)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Julia A Wagner (JA)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Jeffrey W Leong (JW)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Pamela Wong (P)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Annelise Y Mah-Som (AY)

Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, USA.

Terrence N Wong (TN)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Timothy Schappe (T)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Catherine R Keppel (CR)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Victor S Cortez (VS)

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

Efstathios G Stamatiades (EG)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Ming O Li (MO)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Marco Colonna (M)

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

Daniel C Link (DC)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

Anthony R French (AR)

Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, USA.

Megan A Cooper (MA)

Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, USA.

Wei-Le Wang (WL)

Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

Mark P Boldin (MP)

Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

Pavan Reddy (P)

Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.

Todd A Fehniger (TA)

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: tfehnige@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Betaherpesvirinae › Muromegalovirus › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules NIH 3T3 › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-15 › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines SOCS › MicroRNA-142 Is Critical for the Homeostasis...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › MicroRNA-142 Is Critical for the Homeostasis...