T and B-cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity.
APDS/PASLI
T and B lymphocytes
autoimmunity
immunodeficiency
phosphatidylinositol 3 kinase
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
20
05
2019
accepted:
30
05
2019
entrez:
13
8
2019
pubmed:
14
8
2019
medline:
25
2
2020
Statut:
ppublish
Résumé
Phosphatidylinositol 3 kinases (PI3K) are a family of lipid kinases that are activated by a variety of cell-surface receptors, and regulate a wide range of downstream readouts affecting cellular metabolism, growth, survival, differentiation, adhesion, and migration. The importance of these lipid kinases in lymphocyte signaling has recently been highlighted by genetic analyses, including the recognition that both activating and inactivating mutations of the catalytic subunit of PI3Kδ, p110δ, lead to human primary immunodeficiencies. In this article, we discuss how studies on the human genetic disorder "Activated PI3K-delta syndrome" and mouse models of this disease (Pik3cd
Substances chimiques
Biomarkers
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154-173Informations de copyright
Published 2019. This article is a U.S. Government work and is in the public domain in the USA.