Relationship between left atrial volume and ischemic stroke subtype.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
03
2019
revised:
19
06
2019
accepted:
19
06
2019
entrez:
13
8
2019
pubmed:
14
8
2019
medline:
30
5
2020
Statut:
ppublish
Résumé
Atrial cardiopathy without atrial fibrillation (AF) may be a potential cardiac source of embolic strokes of undetermined source (ESUS). Atrial volume is a feature of atrial cardiopathy, but the relationship between atrial volume and ESUS remains unclear. We compared left atrial volume among ischemic stroke subtypes in the Cornell Acute Stroke Academic Registry (CAESAR), which includes all patients with acute ischemic stroke at our hospital since 2011. Stroke subtype was determined by neurologists per the TOAST classification and consensus ESUS definition. Left atrial volume index (LAVI) was obtained directly from our echocardiography image system (Xcelera, Philips Healthcare). We used t-tests and analysis of variance for unadjusted comparisons and targeted minimum loss-based estimation for comparisons adjusted for demographics and comorbidities. Among 2116 patients in CAESAR from 2011 to 2016, 1293 had LAVI measurements. LAVI varied across subtypes (P < 0.001) from 48.8 (±30.0) mL/m We found larger left atria among patients with ESUS versus non-cardioembolic stroke. There was significant overlap in left atrial size between ESUS and non-cardioembolic stroke, highlighting that many ESUS cases are not cardioembolic.
Identifiants
pubmed: 31402612
doi: 10.1002/acn3.50841
pmc: PMC6689681
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1480-1486Subventions
Organisme : NHLBI NIH HHS
ID : R01HL128278
Pays : United States
Organisme : Leon Levy Fellowship in Neuroscience
Pays : International
Organisme : Weill Cornell Medicine Clinical and Translational Science Center
ID : UL1TR000457
Pays : International
Organisme : NINDS NIH HHS
ID : R01 NS097443
Pays : United States
Organisme : American Heart Association
ID : 18CDA34110419
Pays : International
Organisme : Michael Goldberg Research Fund
Pays : International
Organisme : Florence Gould Endowment for Discovery in Stroke
Pays : International
Organisme : NINDS NIH HHS
ID : K23 NS091395
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL140092
Pays : United States
Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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